Document Detail

Association between hemodynamics in the common carotid artery and severity of carotid atherosclerosis in patients with essential hypertension.
MedLine Citation:
PMID:  18451808     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Carotid intima-media thickness (IMT) and plaque burden evaluated by B-mode ultrasound have been used as relevant indicators for carotid atherosclerosis. This study was aimed to investigate the relationship between hemodynamic parameters in the common carotid artery (CCA) and the severity of carotid atherosclerosis in untreated hypertensive patients. METHODS: Carotid IMT and plaque burden were evaluated in bilateral CCA, bifurcations, external and internal carotid arteries using duplex ultrasound in 80 untreated hypertensive patients. The patients were divided into four groups according to plaque burden. Hemodynamic parameters of CCA, including peak and mean circumferential wall tension (CWT), tensile stress (TS), wall shear stress (WSS), and Young's elastic modulus (YEM), were calculated after measurements of internal diameter (ID), IMT, and peak and mean flow velocities of CCA. Arterial stiffness was also assessed using the brachial-ankle pulse wave velocity (baPWV). RESULTS: Age, pulse pressure, creatinine, carotid IMT, and mean TS were shown to have significant differences among the four plaque groups (P < 0.05). Peak CWT and peak TS were also shown to have marginal differences. In univariate analysis, the peak and mean CWT and TS were significantly correlated with plaque score. Stepwise multiple regression analysis showed that carotid IMT, age, and peak CWT were independently associated with plaque score. CONCLUSIONS: These results suggest that the CWT and TS of the CCA are associated with the severity of carotid atherosclerosis in untreated hypertensive patients. Hence, the hemodynamics of vessels may contribute to the plaque burden of low-resistance arteries.
Min Y Lee; Chan M Wu; Kuo H Yu; Chih S Chu; Kun T Lee; Sheng H Sheu; Wen T Lai
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Publication Detail:
Type:  Journal Article     Date:  2008-05-01
Journal Detail:
Title:  American journal of hypertension     Volume:  21     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-10-30     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-70     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply
Blood Flow Velocity
Blood Pressure
Brachial Artery / physiopathology
Carotid Artery Diseases / etiology,  physiopathology*,  ultrasonography
Carotid Artery, Common / physiopathology*,  ultrasonography
Cross-Sectional Studies
Hypertension / complications*,  physiopathology,  ultrasonography
Middle Aged
Models, Cardiovascular
Risk Factors
Severity of Illness Index
Stress, Mechanical
Ultrasonography, Doppler, Duplex
Comment In:
Am J Hypertens. 2008 Jul;21(7):729   [PMID:  18584017 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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