| Association between hemodynamics in the common carotid artery and severity of carotid atherosclerosis in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 18451808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Carotid intima-media thickness (IMT) and plaque burden evaluated by B-mode ultrasound have been used as relevant indicators for carotid atherosclerosis. This study was aimed to investigate the relationship between hemodynamic parameters in the common carotid artery (CCA) and the severity of carotid atherosclerosis in untreated hypertensive patients. METHODS: Carotid IMT and plaque burden were evaluated in bilateral CCA, bifurcations, external and internal carotid arteries using duplex ultrasound in 80 untreated hypertensive patients. The patients were divided into four groups according to plaque burden. Hemodynamic parameters of CCA, including peak and mean circumferential wall tension (CWT), tensile stress (TS), wall shear stress (WSS), and Young's elastic modulus (YEM), were calculated after measurements of internal diameter (ID), IMT, and peak and mean flow velocities of CCA. Arterial stiffness was also assessed using the brachial-ankle pulse wave velocity (baPWV). RESULTS: Age, pulse pressure, creatinine, carotid IMT, and mean TS were shown to have significant differences among the four plaque groups (P < 0.05). Peak CWT and peak TS were also shown to have marginal differences. In univariate analysis, the peak and mean CWT and TS were significantly correlated with plaque score. Stepwise multiple regression analysis showed that carotid IMT, age, and peak CWT were independently associated with plaque score. CONCLUSIONS: These results suggest that the CWT and TS of the CCA are associated with the severity of carotid atherosclerosis in untreated hypertensive patients. Hence, the hemodynamics of vessels may contribute to the plaque burden of low-resistance arteries. |
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Authors:
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Min Y Lee; Chan M Wu; Kuo H Yu; Chih S Chu; Kun T Lee; Sheng H Sheu; Wen T Lai |
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Publication Detail:
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Type: Journal Article Date: 2008-05-01 |
Journal Detail:
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Title: American journal of hypertension Volume: 21 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-27 Completed Date: 2008-10-30 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 765-70 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Ankle / blood supply Blood Flow Velocity Blood Pressure Brachial Artery / physiopathology Carotid Artery Diseases / etiology, physiopathology*, ultrasonography Carotid Artery, Common / physiopathology*, ultrasonography Cross-Sectional Studies Elasticity Female Hemodynamics* Humans Hypertension / complications*, physiopathology, ultrasonography Male Middle Aged Models, Cardiovascular Risk Factors Severity of Illness Index Stress, Mechanical Ultrasonography, Doppler, Duplex |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2008 Jul;21(7):729
[PMID:
18584017
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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