Document Detail


Association between glomerular filtration rate and extracellular fluid volume in normal subjects and patients with renal impairment.
MedLine Citation:
PMID:  18224556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to determine the extent to which glomerular filtration rate (GFR) measured with one filtration marker is associated with extracellular fluid volume (ECV) measured independently with another. Cr-51-EDTA and iohexol were injected simultaneously into opposite arms in 20 normal volunteers and 60 patients. Cubital samples taken bilaterally at 20, 40, 60, 120, 180 and 240 min were assayed for marker injected contralaterally. GFR was scaled to body surface area of 1.73 m(2) (GFR/BSA). GFR was also expressed as marker transit time (GFR/ECV) and ECV as the product of marker transit time and GFR/BSA. In normal subjects, changes between fasting and non-fasting ECV/BSA correlated positively with changes in GFR/BSA, but not GFR/ECV. GFR/BSA and GFR/ECV correlated positively (regression slope approximately 4 ml.min(-1).litre(-1)) and negatively (-2.7 ml x min(-1) x litre(-1)), respectively, with ECV/BSA. The difference, 6.7 ml x min(-1) x litre(-1), expressed as a fraction of average scaled GFR ( approximately 90 ml x min(-1)) is close to the reciprocal of average ECV/BSA (13.5 litres.1.73 m(-2)), consistent with the expected slope of the regression on ECV/BSA of the difference-to-average ratio of GFR/BSA and GFR/ECV. In contrast, in 29 patients with impaired GFR (estimated from plasma creatinine), ECV/BSA correlated inversely with GFR/ECV (slope approximately -5 ml x min(-1) x litre(-1)) but showed no relation with GFR/BSA. We conclude that in normal subjects GFR/BSA increases in response to increasing ECV/BSA, but the increase is not proportionate, leading to a weak inverse association between GFR/ECV and ECV/BSA. When ECV is expanded in patients with renal impairment, however, there is no GFR response, leading to a reduction in GFR/ECV.
Authors:
N J Bird; C Peters; A R Michell; A M Peters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  68     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Body Surface Area
Contrast Media / administration & dosage
Edetic Acid / administration & dosage,  diagnostic use
Extracellular Fluid / physiology*
Fasting / physiology
Female
Glomerular Filtration Rate / physiology*
Humans
Iohexol / administration & dosage,  diagnostic use
Kidney Function Tests
Male
Middle Aged
Nutritional Status / physiology
Renal Insufficiency / physiopathology*
Chemical
Reg. No./Substance:
0/Contrast Media; 60-00-4/Edetic Acid; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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