Document Detail

Association between global brain volume and the rate of cognitive change in elderly humans without dementia.
MedLine Citation:
PMID:  15677869     Owner:  NLM     Status:  MEDLINE    
Patients with mild cognitive deficits experience different types of evolution. They are at increased risk of developing dementia, but they have also a chance of remaining stable in cognition or of improving. We investigated whether global brain volume, callosal size and hippocampal size are associated with the rate of cognitive change in elderly without dementia. Volumetric MR images were recorded from 39 controls and 35 patients with questionable dementia who were followed up longitudinally for a mean of 2.3 years. The outcome measure was the annual change in the test score in the Structured Interview for the Diagnosis of Alzheimer's Dementia and Multi-Infarct Dementia, which includes all items of the Mini-Mental State Examination. Global brain volume, grey matter volume and white matter volume were the only significant independent predictors of the rate of cognitive change.
A Hensel; H Wolf; A Busse; T Arendt; H J Gertz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-25
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  19     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-07-15     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Karolinska Institute, Neurotec, Division of Clinical Geriatrics, Huddinge University Hospital, Stockholm, Sweden.
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MeSH Terms
Aged, 80 and over
Brain / anatomy & histology*,  physiopathology*
Cognition Disorders / diagnosis*,  physiopathology*
Corpus Callosum / anatomy & histology,  physiopathology
Follow-Up Studies
Hippocampus / anatomy & histology,  physiopathology
Magnetic Resonance Imaging
Neuropsychological Tests
Severity of Illness Index

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