Document Detail

Association between gingival crevicular fluid prostaglandin E 2 level and preterm low birth weight.
MedLine Citation:
PMID:  22842264     Owner:  NLM     Status:  In-Data-Review    
Background: Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E 2 (PGE 2 ), may pose a threat to the fetal-placental unit and cause preterm delivery. Aim: This study was conducted to estimate the PGE 2 levels in gingival crevicular fluid (GCF) and to explore the association between GCF-PGE 2 levels and preterm low birth weight (PLBW). Materials and Methods: Twenty-two pregnant patients were selected for the study. GCF samples were collected from these patients before delivery and again at 1 month after delivery. PGE 2 level was estimated using a commercially available ELISA kit (Neogen™). Results: The mean GCF-PGE 2 level was 5.8 ng/ml before parturition and 5.5 ng/ml after parturition, but the difference was not statistically significant. There was negative correlation between PGE 2 levels and gestational age at birth. Conclusion: The study provides weak evidence that there is correlation between GCF-PGE 2 levels and birth outcome. Further clinical trials with large samples are required to confirm the association between GCF-PGE 2 levels and PLBW.
Fouzia Tarannum; Mohamed Faizuddin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of dental research : official publication of Indian Society for Dental Research     Volume:  23     ISSN:  1998-3603     ISO Abbreviation:  Indian J Dent Res     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9202990     Medline TA:  Indian J Dent Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  120     Citation Subset:  D    
Department of Periodontics, MR Ambedkar Dental College and Hospital, Bangalore, Karnataka, India.
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