Document Detail

Association between gestational and environmental events and central nervous system function in 7-year-old children.
MedLine Citation:
PMID:  1165957     Owner:  NLM     Status:  MEDLINE    
The prevalence of variables frequently associated with low birthweight was compared in samples of low-birthweight (LBW) infants and normal-birthweight infants (single births of the white race) drawn from the Boston component of the Collaborative Perinatal Research Project. Then the association between these exposure variables and central nervous system function at 7 years was examined in the LBW infants. Finally the interrelationships of the five variables having the strongest association with abnormal or suspect CNS function were examined with regard to their joint predictive utility. A high-risk subgroup (10%) of the total LBW group having a greater than 50:50 chance of falling into an adverse category at age 7 was identified by various combinations of the factors: gestational age of 33 weeks or less, premature rupture of membranes, low Apgar score, and respiratory distress. Small subgroups thus defined should receive special attention in follow-up, particularly in relation to the new regional perinatal care centers. They might also be selected for special study of the mechanisms of interference with central nervous system development. In a population of 7-year-old children with abnormal or suspect CNS function as defined by the protocol of this study, 80% will have a history of normal birthweight.
J E Drorbaugh; D M Moore; J H Warram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  56     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-12-12     Completed Date:  1975-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-37     Citation Subset:  AIM; IM    
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MeSH Terms
Apgar Score
Birth Weight*
Educational Status
Fetal Diseases
Gestational Age
Infant, Newborn
Maternal Age
Obstetric Labor Complications
Pregnancy Complications
Respiratory Distress Syndrome, Newborn
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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