Document Detail


Association between gait asymmetry and brain lesion location in stroke patients.
MedLine Citation:
PMID:  19109546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Associations between the site of brain injury and poststroke gait impairment are poorly understood. Temporal gait asymmetry after stroke is a salient index of gait dysfunction that has important functional consequences. The current study investigated whether subtraction lesion analysis could distinguish brain regions associated with persisting temporal gait asymmetry in chronic stroke patients. METHODS: Analysis was conducted on 37 chronic ambulatory stroke patients (17 symmetrical gait, 20 asymmetrical gait). Spatiotemporal gait parameters were recorded using an instrumented walking surface. Lesions were traced from 3D T1-MRI, and region of interest images were generated. The lesion overlay of patients with symmetrical gait was subtracted from patients with asymmetrical gait to highlight voxels more frequently lesioned in asymmetrical patients and relatively spared in symmetrical patients. RESULTS: Demographic data were comparable between the 2 groups. Asymmetrical patients exhibited significantly higher National Institute of Health Stroke Scale neglect scores and more severe motor impairment. Gait asymmetry was significantly correlated to Chedoke-McMaster Stroke Scale leg (r=-0.767, P<0.001) and foot (r=-0.759, P<0.001) scores, whereas gait speed correlated less strongly. After subtraction analysis, injury to the posterolateral putamen was evident 60% to 80% more frequently in the asymmetrical group compared to the symmetrical group. CONCLUSIONS: In this sample of ambulatory chronic stroke patients, damage to the posterolateral putamen was associated with temporal gait asymmetry. Further advances in our understanding of the neural correlates of gait asymmetry may provide prognostic markers for future persistent gait dysfunction and lead to early targeted rehabilitation when key regions are damaged.
Authors:
Lisa D Alexander; Sandra E Black; Kara K Patterson; Fuqiang Gao; Cynthia J Danells; William E McIlroy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-24
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  537-44     Citation Subset:  IM    
Affiliation:
Heart and Stroke Foundation Centre for Stroke Recovery, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / physiology
Brain / pathology*
Cross-Sectional Studies
Female
Foot / physiology
Functional Laterality / physiology
Gait / physiology
Gait Disorders, Neurologic / complications*,  pathology,  physiopathology
Humans
Image Processing, Computer-Assisted
Leg / physiology
Magnetic Resonance Imaging
Male
Middle Aged
Putamen / pathology
Stroke / etiology*,  pathology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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