Document Detail

Association between foeto-maternal bleeding and hypertension in pregnancy.
MedLine Citation:
PMID:  4186729     Owner:  NLM     Status:  MEDLINE    
A blind prospective survey of foeto-maternal bleeding in 200 primiparous pregnancies was carried out in an investigation of a possible association between foeto-maternal bleeding and hypertension in pregnancy. Evidence of foeto-maternal bleeding was found in 61% of 36 hypertensive pregnancies, and in 51% of 160 normotensive pregnancies, a difference which is not statistically significant.Significant differences between the hypertensive and the normotensive groups were found when foeto-maternal bleeding was related to gestation. In pregnancies that became hypertensive more foetal cells were found in the maternal circulation before week 36 than in normotensive pregnancies. In patients with oedema of the abdominal wall during pregnancy the incidence of foeto-maternal bleeding was significantly increased.These findings seem to explain why pre-eclamptic toxaemia is a significant predisposing factor in women who later develop Rh antibodies. It is recommended that anti-D gammaglobulin should be offered to all Rh-negative women with Rh-positive infants following a hypertensive pregnancy. Consideration should also be given to the question of administering anti-D gammaglobulin during Rh-negative hypertensive pregnancies if this procedure is proved to be both safe to mother and foetus and effective.The results provide contributory evidence that the placental vascular changes in toxaemic pregnancies precede the clinical signs and are not the result of hypertension.
P Jones; A McNay; W Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 Sep 
Date Detail:
Created Date:  1969-12-06     Completed Date:  1969-12-06     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  738-42     Citation Subset:  AIM; IM    
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MeSH Terms
Albuminuria / complications
Blood Cell Count
Edema / complications
Erythroblastosis, Fetal / prevention & control
Fetomaternal Transfusion*
Gestational Age
Pre-Eclampsia / complications
Pregnancy Complications, Cardiovascular*
Rh-Hr Blood-Group System
Statistics as Topic
gamma-Globulins / therapeutic use
Reg. No./Substance:
0/Rh-Hr Blood-Group System; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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