Document Detail


Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.
MedLine Citation:
PMID:  19786898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.
METHODS: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.
RESULTS: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.
CONCLUSIONS: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
Authors:
Jee Young Kim; Lacey A Prouty; Shona C Fang; Ema G Rodrigues; Shannon R Magari; Geoffrey A Modest; David C Christiani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  51     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-02-01     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1158-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Air Pollutants / adverse effects*,  analysis
Case-Control Studies
DNA Damage*
Deoxyguanosine / analogs & derivatives*,  urine
Female
Humans
Hypertension / complications*,  genetics,  urine
Male
Middle Aged
Oxidation-Reduction
Particulate Matter / adverse effects*,  analysis
Young Adult
Grant Support
ID/Acronym/Agency:
ES00002/ES/NIEHS NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; P30 ES000002-409009/ES/NIEHS NIH HHS; R01 ES009860/ES/NIEHS NIH HHS; R01 ES009860-06/ES/NIEHS NIH HHS; T32 ES007069/ES/NIEHS NIH HHS; T32 ES007069/ES/NIEHS NIH HHS; T32 ES007069-26/ES/NIEHS NIH HHS; T42 OH008416/OH/NIOSH CDC HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Particulate Matter; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; G9481N71RO/Deoxyguanosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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