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Association between essential tremor and blood lead concentration.
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MedLine Citation:
PMID:  14594619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lead is a ubiquitous toxicant that causes tremor and cerebellar damage. Essential tremor (ET) is a highly prevalent neurologic disease associated with cerebellar involvement. Although environmental toxicants may play a role in ET etiology and their identification is a critical step in disease prevention, these toxicants have received little attention. Our objective was to test the hypothesis that ET is associated with lead exposure. Therefore, blood lead (BPb) concentrations were measured and a lifetime occupational history was assessed in ET patients and in controls. We frequency matched 100 ET patients and 143 controls on age, sex, and ethnicity. BPb concentrations were analyzed using graphite furnace atomic absorption spectrophotometry. A lifetime occupational history was reviewed by an industrial hygienist. BPb concentrations were higher in ET patients than in controls (mean +/- SD, 3.3 +/- 2.4 and 2.6 +/- 1.6 microg/dL, respectively; median, 2.7 and 2.3 microg/dL; p = 0.038). In a logistic regression model, BPb concentration was associated with diagnosis [control vs. ET patient, odds ratio (OR) per unit increase = 1.21; 95% confidence interval (CI), 1.05-1.39; p = 0.007]. BPb concentration was associated with diagnosis (OR per unit increase = 1.19; 95% CI, 1.03-1.37; p = 0.02) after adjusting for potential confounders. Prevalence of lifetime occupational lead exposure was similar in ET patients and controls. We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation.
Authors:
Elan D Louis; Eva C Jurewicz; LaKeisha Applegate; Pam Factor-Litvak; Michael Parides; Leslie Andrews; Vesna Slavkovich; Joseph H Graziano; Spencer Carroll; Andrew Todd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Environmental health perspectives     Volume:  111     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-03-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1707-11     Citation Subset:  IM    
Affiliation:
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA. EDL2@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Essential Tremor / etiology*,  physiopathology
Female
Humans
Kinetics
Lead / blood*,  pharmacokinetics
Lead Poisoning / complications*
Male
Middle Aged
Occupational Exposure*
Grant Support
ID/Acronym/Agency:
P30 ES09089/ES/NIEHS NIH HHS; R01 NS39422/NS/NINDS NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 11 Year: 2003
Volume: 111 Issue: 14
First Page: 1707 Last Page: 1711
ID: 1241711
PubMed Id: 14594619

Association between essential tremor and blood lead concentration.
Elan D Louis
Eva C Jurewicz
LaKeisha Applegate
Pam Factor-Litvak
Michael Parides
Leslie Andrews
Vesna Slavkovich
Joseph H Graziano
Spencer Carroll
Andrew Todd
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA. EDL2@columbia.edu


Article Categories:
  • Research Article


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