| Association between equine temperament and polymorphisms in dopamine D4 receptor gene. | |
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MedLine Citation:
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PMID: 16151699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The variable number of tandem repeats (VNTR) polymorphism of the dopamine D4 receptor (DRD4) gene has been reported to be associated with the personality trait of novelty-seeking in humans. In the genus Equus, this region includes an 18-bp repeat unit and there are inter- and intraspecies differences in the number of repetitions. Because horses are unique among livestock species in that their temperament is considered important, we investigated the possible role of this region on equine temperament in thoroughbred horses. We simultaneously determined the sequences of this polymorphic region and administered a questionnaire survey to horse caretakers with questions about 20 different traits of their horses' temperament. Although there was no difference in the number of repeats among the 136 thoroughbred horses studied, two single nucleotide polymorphisms (SNPs), one of which might cause an amino acid change (A-G substitution), existed. By analyzing the association between these SNPs and temperament scores, a significant association was revealed between two temperament traits (Curiosity and Vigilance) and the A-G substitution. Horses without the A allele had significantly higher Curiosity and lower Vigilance scores than those with the A allele at the A-G substitution. In addition, similar associations between both temperament scores and each genotype of the A-G substitution were observed in two subgroups divided according to the time of their introduction to the farm. These results suggested that the SNP in the VNTR region of the equine DRD4 gene might be related to individual differences in equine temperament. |
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Authors:
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Yukihide Momozawa; Yukari Takeuchi; Ryo Kusunose; Takefumi Kikusui; Yuji Mori |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mammalian genome : official journal of the International Mammalian Genome Society Volume: 16 ISSN: 0938-8990 ISO Abbreviation: Mamm. Genome Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-09-09 Completed Date: 2006-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100916 Medline TA: Mamm Genome Country: United States |
Other Details:
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Languages: eng Pagination: 538-44 Citation Subset: IM |
Affiliation:
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Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, Tokyo, 113-8657, Japan, |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence DNA Primers Horses / genetics*, physiology Minisatellite Repeats / genetics* Molecular Sequence Data Mutation / genetics Polymorphism, Single Nucleotide* Questionnaires Receptors, Dopamine D4 / genetics* Sequence Analysis, DNA Temperament / physiology* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 137750-34-6/Receptors, Dopamine D4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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