Document Detail

Association between different measures of blood pressure and coronary artery calcium in postmenopausal women.
MedLine Citation:
PMID:  18794404     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the magnitude and significance of the associations among coronary artery calcium (CAC) and systolic blood pressure, diastolic blood pressure, pulse pressure, and mean arterial pressure. Women 50 to 59 years of age at baseline in the Women's Health Initiative clinical trial of conjugated equine estrogen underwent computed tomography scanning of the chest after the end of the trial. Blood pressures were measured twice with the participant in the seated position using a conventional mercury sphygmomanometer. The study included 1064 women with a mean age of 55.1 (2.8) years. The prevalence of a CAC score >0, >or=10, and >100 was 47%, 39%, and 19%, respectively. There was a linear association between the log-odds of any CAC and systolic blood pressure, whereas there was a curvilinear and inverse association with diastolic blood pressure. For any value of diastolic blood pressure, the probability of CAC increased with higher levels of systolic blood pressure, whereas for any given value of systolic blood pressure, the probability of any CAC decreased with higher levels of diastolic blood pressure. Also, a pulse pressure >or=55 mm Hg was associated with a higher odds (1.95; 95% CI, 1.24 to 3.06) for having any CAC, whereas individuals with isolated systolic hypertension had a 73% higher odds for CAC >0 (95% CI, 1.03 to 2.90; P=0.04). In postmenopausal women, higher levels of pulse pressure and systolic blood pressure were strong determinants of CAC, whereas diastolic blood pressure was inversely related.
Matthew A Allison; Joann E Manson; Robert D Langer; Aaron Aragaki; Sylvia Smoller; Cora E Lewis; Asha Thomas; William Lawson; Barbara B Cochrane; Judith Hsia; Julie R Hunt; Jennifer Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-15
Journal Detail:
Title:  Hypertension     Volume:  52     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-23     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-40     Citation Subset:  IM    
University of California San Diego, La Jolla, California, USA.
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MeSH Terms
Blood Pressure / physiology*
Calcium / metabolism*
Cardiovascular Diseases / epidemiology
Coronary Angiography
Coronary Vessels / metabolism*
Diastole / physiology
Hypertension / epidemiology
Middle Aged
Odds Ratio
Postmenopause / physiology*
Prospective Studies
Risk Factors
Systole / physiology
Tomography, X-Ray Computed
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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