Document Detail


Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.
MedLine Citation:
PMID:  22217675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to assess whether cytochrome P450 enzyme 2A6 (CYP2A6) genotypes moderate the association between smoking and hypertension. In this study, 954 Chinese male current smokers from a community-based chronic disease screening project in Guangzhou were interviewed with a structured questionnaire about socio-demographic status, smoking and other health-related behaviors. Blood was collected for DNA extraction and CYP2A6 genotyping. Hypertension was defined according to 2007 ESH-ESC Practice Guidelines. A multivariate logistic regression was performed to examine the interaction between smoking quantity and CYP2A6 genotypes on hypertension after adjusting for age, education level and other potential confounders. Multivariate analyses indicated that smoking more than 15 cigarettes per day significantly increased the risk of hypertension (odds ratio (OR)=1.59, 95% confidence interval (CI)=1.21-2.10) compared with smoking 1-15 cigarettes per day, and further suggested that smoking interacted with normal CYP2A6 metabolizer genotype to increase the risk of hypertension. Smokers consuming more than 15 cigarettes per day with normal CYP2A6 metabolizer genotypes had the highest risk of hypertension (OR=2.04, 95% CI=1.11-3.75) compared with those consuming 1-15 cigarettes per day with slower CYP2A6 metabolizer genotypes. These findings demonstrated that smoking quantity was positively associated with hypertension and that CYP2A6 genotypes may moderate this relationship.
Authors:
T Liu; R F Tyndale; S P David; H Wang; X-Q Yu; W Chen; X-Z Wen; W-Q Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-05
Journal Detail:
Title:  Journal of human hypertension     Volume:  27     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-05     Completed Date:  2013-07-26     Revised Date:  2014-08-14    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aryl Hydrocarbon Hydroxylases / genetics*
Asian Continental Ancestry Group / genetics*
Cross-Sectional Studies
Female
Genotype
Humans
Hypertension / etiology,  genetics*
Logistic Models
Male
Smoking / adverse effects*
Grant Support
ID/Acronym/Agency:
K08-014276//PHS HHS; R21 DA027331/DA/NIDA NIH HHS; R21-027331//PHS HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
EC 1.14.13.-/coumarin 7-hydroxylase; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases
Comments/Corrections

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