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Association between cystatin C and inflammation in patients with essential hypertension.
MedLine Citation:
PMID:  20809110     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death. It is known that the initiation and progression of these cardiovascular events contributes to renal dysfunction and chronic inflammation. In this study, we investigated the relationship between cystatin C and proinflammatory cytokines.
METHODS: Eighty-eight patients with essential hypertension participated in the study, which involved measuring proinflammatory cytokines, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and C reactive protein (CRP).
RESULTS: Positive correlations were detected between cystatin C and estimated glomerular filtration rate (eGFR) (r = -0.503, p < 0.001), systolic blood pressure (r = -0.246, p = 0.034), and pulse pressure (r = -0.295, p = 0.010). In contrast, serum creatinine correlated only with eGFR (r = -0.755, p < 0.001) and eGFR correlated only with age (r = -0.339, p = 0.001) and not with the other clinical parameters, whereas cystatin C also correlated with log natural (ln) IL-6 (r = -0.247, p = 0.033) and ln TNF-α (r = -0.405, p < 0.001) but not with CRP (r = -0.188, p = 0.108). In contrast, plasma creatinine and eGFR did not correlate with any of these proinflammatory cytokines. Stepwise regression analysis showed that ln TNF-α, eGFR and pulse pressure were independent determinants of serum cystatin C concentration.
CONCLUSION: This study showed that cystatin C is a marker of inflammation as well as renal function.
Authors:
Takafumi Okura; Masanori Jotoku; Jun Irita; Daijiro Enomoto; Tomoaki Nagao; Veena Rasika Desilva; Shiho Yamane; Zuowei Pei; Shiho Kojima; Yasuyuki Hamano; Shinichi Mashiba; Mie Kurata; Ken-ichi Miyoshi; Jitsuo Higaki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-31
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  14     ISSN:  1437-7799     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  584-8     Citation Subset:  IM    
Affiliation:
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan. okura@m.ehime-u.ac.jp
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