| Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries. | |
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MedLine Citation:
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PMID: 12956400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined a possibility whether or not severity and extent of coronary atherosclerosis may associate with degree of local inflammation in relation to endothelial dysfunction as is indicated by reduced NO formation. Blood samples were obtained from aortic root (Ao) and coronary sinus (CS) of 39 patients who underwent coronary angiography. Plasma NOx levels (nitrite + nitrate, stable NO end-products) were evaluated by HPLC-Griess system, and markers of inflammation, C-reactive protein (CRP) and serum amyloid A protein (SAA), were measured by Latex Turbidimetric Immunoassay. To evaluate the changes of these substances through coronary circulation, the percentage changes of respective markers [(CS - Ao) x 100/Ao] were calculated. The extent and severity of atherosclerosis of left coronary arteries were evaluated with Gensini Score (GS). The GS correlated with the percentage changes of NOx (r = -0.35, p < 0.05) and that of SAA (r = 0.43, p < 0.05) across coronary circulation, but not with changes in CRP. Moreover, the percentage changes of NOx correlated with that of SAA (r = -0.36, p < 0.05). These results indicated that severity and extent of coronary atherosclerosis related to degree of local inflammation which has a possible association with coronary endothelial dysfunction. |
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Authors:
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Taku Matsubara; Takaharu Ishibashi; Tomoyuki Hori; Kazuyuki Ozaki; Tohru Mezaki; Keiichi Tsuchida; Akimitsu Nasuno; Kaname Kubota; Takayuki Tanaka; Takashi Miida; Yoshifusa Aizawa; Matomo Nishio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 249 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-09-05 Completed Date: 2004-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Shinrakuen Hospital, Niigata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood C-Reactive Protein / metabolism Coronary Angiography Coronary Artery Disease / blood, pathology*, physiopathology* Coronary Circulation Coronary Vessels / physiopathology* Endothelium, Vascular / pathology* Humans Inflammation / physiopathology* Nitric Oxide / blood Nitrites / blood Serum Amyloid A Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrites; 0/Serum Amyloid A Protein; 10102-43-9/Nitric Oxide; 9007-41-4/C-Reactive Protein |
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