Document Detail


Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm.
MedLine Citation:
PMID:  20031540     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent genome-wide studies have shown a significant association of a locus on chromosome 9p21.3 and coronary artery disease. We performed a case-control study to investigate the association between this locus and abdominal aortic aneurysm (AAA). METHODS AND RESULTS: A total of 1714 patients (899 patients with AAA and 815 controls) were genotyped for the lead single-nucleotide polymorphism, rs1333049, on chromosome 9p21. The frequency of the C (risk) allele of rs1333049 in the control group was 0.471. There was a significant association between the C allele and AAA (odds ratio, 1.22; 95% confidence interval, 1.06 to 1.39; P=0.004). The genotypic-specific odds ratios (compared with the GG genotype) were 1.17 (95% confidence interval, 0.93 to 1.47; P=0.191) for the GC genotype and 1.50 (95% confidence interval, 1.14 to 1.97; P=0.004) for the CC genotype. In logistic regression modeling, the association of the CC genotype with AAA was independent of the presence of clinical coronary artery disease (odds ratio, 1.46; 95% confidence interval, 1.11 to 1.94; P=0.008). CONCLUSIONS: Our study shows that the recently identified chromosome 9 variant that increases risk of coronary artery disease is also associated with the presence of AAA. The findings suggest that the effect of this locus on risk of cardiovascular disease extends beyond the coronary circulation.
Authors:
Matthew J Bown; Peter S Braund; John Thompson; Nicholas J M London; Nilesh J Samani; Robert D Sayers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  1     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-42     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. m.bown@le.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal / complications*,  genetics*
Case-Control Studies
Chromosomes, Human, Pair 9 / genetics*
Coronary Artery Disease / complications*,  genetics*
Demography
Female
Gene Frequency / genetics
Genetic Loci / genetics*
Genetic Predisposition to Disease*
Humans
Logistic Models
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide / genetics
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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