Document Detail

Association between coronary artery calcification score as assessed by multi-detector row computed tomography and upstroke time of pulse wave.
MedLine Citation:
PMID:  18025764     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The coronary artery calcification (CAC) score determined by multi-detector row computed tomography (MDCT) predicts the onset of coronary artery disease (CAD). In addition, pulse wave velocity (PWV) also predicts the mortality of CAD. Therefore, the aim of this study was to assess whether or not the CAC score is associated with PWV. METHODS AND RESULTS: The subjects consisted of 535 consecutive patients with suspected CAD who underwent MDCT. Brachial-ankle (ba) PWV, ankle-brachial index, % mean artery pressure (MAP) and upstroke time (UT) were measured. When the subjects were divided into three groups according to the CAC score [low (0-12 IU), intermediate (13-445) and high (> or = 445)], the classification score was significantly associated with age, sex, prevalence of hypertension and diabetes mellitus, systolic blood pressure, plasma levels of high-density lipoprotein cholesterol and uric acid, medication by angiotensin II receptor blocker and calcium channel blocker, PWV, %MAP and UT. In a multivariate logistic regression analysis, UT (p<0.0001), sex (p=0.0001), age (p=0.0003) and PWV (p=0.0276) remained significant independent variables for the classification. CONCLUSIONS: UT was most significantly associated with the classification according to the CAC score. Measurement of UT should be performed before MDCT angiography, because the assessment of coronary artery lumen narrowing by MDCT can not be diagnosed in patients with severe calcification.
Ryoko Mitsutake; Shin-ichiro Miura; Keijiro Saku
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-11-16
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-20     Completed Date:  2007-12-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1833-6     Citation Subset:  IM    
Department of Cardiology, Fukuoka University School of Medicine.
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MeSH Terms
Blood Pressure*
Brachial Artery
Calcinosis* / classification,  radiography
Cohort Studies
Coronary Artery Disease / pathology,  radiography*
Middle Aged
Predictive Value of Tests
Pulsatile Flow
Tomography, X-Ray Computed / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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