| Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus. | |
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MedLine Citation:
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PMID: 22264780 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA+AG genotypes were significantly associated with NODAT-risk (p=0.004; OR=2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association. |
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Authors:
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Beatriz Tavira; Eliecer Coto; Armando Torres; Carmen Díaz-Corte; Beatriz Díaz-Molina; Francisco Ortega; Manuel Arias; Juan M Díaz; Rafael Selgas; Carlos López-Larrea; Marta Ruiz-Ortega; Alberto Ortiz; Elena González; Josep M Campistol; Victoria Alvarez; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-4 |
Journal Detail:
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Title: Molecular genetics and metabolism Volume: - ISSN: 1096-7206 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9805456 Medline TA: Mol Genet Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Genética Molecular, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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