| Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach. | |
| | |
MedLine Citation:
|
PMID: 21975278 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: We used propensity scores matching techniques to assess the association between maternal cocaine abuse in pregnancy and the occurrence of placenta-associated syndromes (PAS). STUDY DESIGN: Mothers who abused cocaine (n=5026) were matched to controls (n=5026) from a sample of 1,693,197, unexposed mothers in Florida from 1998 to 2007. Cocaine abuse was identified using the ICD-9 principal and secondary diagnosis codes (304.2 for cocaine dependence and 305.6 for cocaine abuse). The outcome of interest, PAS, was identified as any indication in diagnosis field of ICD-9-CM codes for: placental abruption (641.2), oligohydramnios (658.0), placental infarction (656.7, 656.8, 656.9), gestational hypertension (642.3, 642.9), preeclampsia (642.4, 642.5, and 642.7) or eclampsia (642.6). RESULTS: Nearly 6% of mothers in the study sample experienced a condition associated with PAS prior to matching. Women who abused cocaine were 58% more likely to have PAS when compared to women who did not (OR=1.48, 95% confidence interval: 1.33, 1.66). Women who abused cocaine were at elevated odds for placental abruption, placenta infarction and preeclampsia with the most pronounced odds noted for placental abruption (OR=2.79, 95% confidence interval: 2.19, 3.55). CONCLUSIONS: These findings indicate that cocaine abuse during pregnancy is associated with more placenta-related disorders than previously reported. |
| | |
Authors:
|
Alfred K Mbah; Amina P Alio; Doris W Fombo; Karen Bruder; Getachew Dagne; Hamisu M Salihu |
Related Documents
:
|
10780188 - Addressing the dramatic rise in multiple pregnancies. 19293388 - As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in... 2709178 - Spontaneous rupture of the liver during pregnancy: a case report. 18417038 - Pregnancy and liver disease. 19491318 - Adverse effects of antiretrovirals in hiv-infected pregnant women. 16123678 - Protease inhibitor use in 233 pregnancies. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-3 |
Journal Detail:
|
Title: Early human development Volume: - ISSN: 1872-6232 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Published by Elsevier Ireland Ltd. |
Affiliation:
|
Department of Epidemiology and Biostatistics, University of South Florida, Tampa, FL 33612, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The health impact of social disadvantage in early childhood; the Generation R study.
Next Document: Maternal Pregnancy Levels of Trans-Nonachlor and Oxychlordane and Prevalence of Cryptorchidism and H...