| Association between circulating white blood cell count and cancer mortality: a population-based cohort study. | |
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MedLine Citation:
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PMID: 16432087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammatory processes are implicated in the development and progression of cancer. However, it is not clear whether systemic markers of inflammation predict cancer. We examined the prospective relationship between circulating white blood cell (WBC) count and cancer mortality. METHODS: Population-based cohort study of 3189 individuals, aged 49 to 84 years and free of cancer at the baseline examination (January 1, 1992, to December 31, 1994), in the Blue Mountains region, west of Sydney, Australia. The main outcome of interest was all cancer mortality ascertained from vital status as of December 31, 2001. RESULTS: Higher WBC count was found to be associated with all cancer mortality. In proportional hazards models adjusting for age, sex, education, body mass index, hematocrit level, alcohol consumption, physical inactivity, smoking, weekly aspirin use, diabetes mellitus or fasting hyperglycemia status, and fasting glucose levels, the multivariable relative risk of all cancer mortality comparing quartile 4 of WBC count ( > or = 7400 cells/microL) with quartile 1 (< or = 5300 cells/microL) was 1.73 (95% confidence interval [CI], 1.18-2.55). In subgroup analyses, the relative risk of cancer mortality comparing quartile 4 of WBC count with quartile 1 was higher among those with diabetes or fasting hyperglycemia (3.03 [95% CI, 1.01-9.15]) than among those with normoglycemia (1.68 [95% CI, 1.12-2.52]). Also, the relative risk of cancer mortality associated with joint exposure to quartile 4 of WBC count and aspirin nonuse was 2.42 (95% CI, 1.46-4.01) compared with their absence. CONCLUSION: These data provide new epidemiological evidence of an association between circulating WBC count, a widely available marker of inflammation, and subsequent cancer mortality. |
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Authors:
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Anoop Shankar; Jie Jin Wang; Elena Rochtchina; Mimi C Yu; Richard Kefford; Paul Mitchell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of internal medicine Volume: 166 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 188-94 Citation Subset: AIM; IM |
Affiliation:
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Division of Epidemiology, Department of Community, Occupational, and Family Medicine and the Centre for Molecular Epidemiology, National University of Singapore, Singapore. ashankar@nus.edu.sg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Australia / epidemiology Cause of Death* Cohort Studies Confidence Intervals Female Follow-Up Studies Humans Leukocyte Count* Leukocyte Disorders / diagnosis Lung Neoplasms / blood, mortality, pathology Male Middle Aged Multivariate Analysis Neoplasm Staging Neoplasms / blood*, mortality*, pathology Probability Risk Assessment Sensitivity and Specificity Survival Analysis Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
| Comments/Corrections | |
Erratum In:
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Arch Intern Med. 2006 Mar 27;166(6):681 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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