Document Detail


Association between circulating specific leukocyte types and blood pressure: the atherosclerosis risk in communities (ARIC) study.
MedLine Citation:
PMID:  20980213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although total white blood cell (WBC) count has been associated with hypertension, the association between specific WBC types and blood pressure (BP) levels has not been studied. In a cohort of 5746 middle-age African-American and white adults free of clinical cardiovascular disease and cancer and not taking hypertension or anti-inflammatory medications, BP was measured at baseline and 3, 6, and 9 years later. Levels of circulating neutrophils, lymphocytes, and monocytes were measured at baseline. In African-Americans, but much less so in whites, increased neutrophil levels and decreased lymphocyte levels were significantly associated with elevation of BP but did not influence the rate of change of BP over time. The mean BP difference between the highest and lowest quartiles of neutrophils was approximately 8 mm Hg for systolic BP (SBP), 4 mm Hg for mean arterial pressure (MAP), and 5 mm Hg for pulse pressure (PP). The mean BP difference between the lowest and highest quartiles of lymphocytes was approximately 6 mm Hg for SBP, 2 mm Hg for diastolic BP (DBP), 3 mm Hg for MAP, and 4 mm Hg for PP. Increased neutrophils and decreased lymphocytes are significantly correlated with the regulation of BP and the development of hypertension, especially in African-Americans.
Authors:
Niu Tian; Alan D Penman; Anthony R Mawson; R Davis Manning; Michael F Flessner
Related Documents :
1611813 - Treatment of preeclampsia and eclampsia.
22481693 - Exercise training program based on minimum weekly frequencies: effects on blood pressur...
2953943 - Therapeutic actions of alpha-human atrial natriuretic polypeptide in 16 clinical cases.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-27
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  4     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-02-16     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-83     Citation Subset:  IM    
Copyright Information:
2010 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. nitan@umc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group
Aged
Blood Pressure*
Cross-Sectional Studies
Diastole
European Continental Ancestry Group
Female
Humans
Leukocytes / metabolism*
Male
Middle Aged
Prospective Studies
Regression Analysis
Systole
United States
Grant Support
ID/Acronym/Agency:
N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Employment of mid-level providers in primary care and control of diabetes.
Next Document:  Renal dysfunction impairs circadian variation of endothelial function in patients with essential hyp...