| Association between circulating specific leukocyte types and blood pressure: the atherosclerosis risk in communities (ARIC) study. | |
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MedLine Citation:
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PMID: 20980213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although total white blood cell (WBC) count has been associated with hypertension, the association between specific WBC types and blood pressure (BP) levels has not been studied. In a cohort of 5746 middle-age African-American and white adults free of clinical cardiovascular disease and cancer and not taking hypertension or anti-inflammatory medications, BP was measured at baseline and 3, 6, and 9 years later. Levels of circulating neutrophils, lymphocytes, and monocytes were measured at baseline. In African-Americans, but much less so in whites, increased neutrophil levels and decreased lymphocyte levels were significantly associated with elevation of BP but did not influence the rate of change of BP over time. The mean BP difference between the highest and lowest quartiles of neutrophils was approximately 8 mm Hg for systolic BP (SBP), 4 mm Hg for mean arterial pressure (MAP), and 5 mm Hg for pulse pressure (PP). The mean BP difference between the lowest and highest quartiles of lymphocytes was approximately 6 mm Hg for SBP, 2 mm Hg for diastolic BP (DBP), 3 mm Hg for MAP, and 4 mm Hg for PP. Increased neutrophils and decreased lymphocytes are significantly correlated with the regulation of BP and the development of hypertension, especially in African-Americans. |
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Authors:
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Niu Tian; Alan D Penman; Anthony R Mawson; R Davis Manning; Michael F Flessner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-27 |
Journal Detail:
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Title: Journal of the American Society of Hypertension : JASH Volume: 4 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-02-16 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 272-83 Citation Subset: IM |
Copyright Information:
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2010 American Society of Hypertension. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. nitan@umc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group Aged Blood Pressure* Cross-Sectional Studies Diastole European Continental Ancestry Group Female Humans Leukocytes / metabolism* Male Middle Aged Prospective Studies Regression Analysis Systole United States |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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