| Association between cholecystokinin type A receptor haplotypes and growth traits in Japanese Hinai-dori crossbred chickens. | |
| | |
MedLine Citation:
|
PMID: 21947885 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We previously identified quantitative trait loci for body weight and average daily gain in a common region between MCW0240 (chr 4: 69.9 Mb) and ABR0622 (chr 4: 86.3 Mb) on chicken chromosome 4 in an F(2) resource population produced by crossing low- and high-growth lines of the Hinai-dori breed. Cholecystokinin type A receptor (CCKAR) is a candidate gene affecting growth traits in the region. In this study, we genotyped polymorphisms of the CCKAR gene and investigated its association with growth traits in a Hinai-dori F(2) intercross population. All the exons of the CCKAR gene in the parental population were subjected to PCR amplification, nucleotide sequenced and haplotypes identified. To distinguish resultant diplotype individuals in the F(2) population, a mismatch amplification mutation assay was performed. Five haplotypes (Haplotypes 1-5) were accordingly identified. Six genotypes produced by the combination of three haplotypes (Haplotype 1, 3, and 4) were examined in order to identify associations between CCKAR haplotypes and growth traits. The data indicate that Haplotype 1 was superior to Haplotype 3 and 4 in body weight at 10 and 14 weeks of age, average daily gain between 4 and 10 weeks, 10 and 14 weeks, and 0 and 14 weeks of age. It was concluded that CCKAR is a useful marker of growth traits and could be used to develop strategies for improving growth traits in the Hinai-dori breed. |
| | |
Authors:
|
Kazuhiro Rikimaru; Megumi Komatsu; Keiichi Suzuki; Yoshinobu Uemoto; Hisato Takeda; Hideaki Takahashi |
Related Documents
:
|
21844335 - Sunflower domestication alleles support single domestication center in eastern north am... 10628875 - Wild-type and mutant alleles of the aspergillus nidulans developmental regulator gene b... 22169395 - Mutations in ubqln2 are rare in french amyotrophic lateral sclerosis. 21616505 - Notch3 gene mutations in subjects clinically suspected of cadasil. 19107205 - Evidence of repeated and independent saltational evolution in a peculiar genus of sphin... 20880255 - Protein s inherited qualitative deficiency: novel mutations and phenotypic influence. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-25 |
Journal Detail:
|
Title: Molecular biology reports Volume: - ISSN: 1573-4978 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Livestock Experiment Station, Akita Prefectural Agriculture, Forestry, and Fisheries Research Center, Daisen, 019-1701, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structural characterization of plant defensin protein superfamily.
Next Document: Effects of isoflurane exposure during pregnancy on postnatal memory and learning in offspring rats.