Document Detail

Association between chloroform levels in finished drinking water supplies and various site-specific cancer mortality rates.
MedLine Citation:
PMID:  422940     Owner:  NLM     Status:  MEDLINE    
This paper discusses some of the statistical and biological problems that are likely to be encountered when an indirect or ecological approach is used to assess the possible public health impact of general population exposures to environmental agents. For purposes of illustration, the potential association between various site-specific cancer mortality rates and chloroform levels in public drinking water supplies was considered. The analyses that were performed demonstrated that, for the data sets under consideration, there were some definite associations between chloroform levels and cancer mortality for specific sites such as the rectum-intestine and bladder. However, the marked extent to which these results were dependent on (1) the weighting scheme adopted in the analysis, (2) the presumed appropriateness of the data, and (3) the characteristics of the statistical model was also clearly illustrated. Because of these dependencies the quantitative, causal interpretation of results generated from an indirect study would appear to be a very tenuous and questionable practice in most instances.
M D Hogan; P Y Chi; D G Hoel; T J Mitchell
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of environmental pathology and toxicology     Volume:  2     ISSN:  0146-4779     ISO Abbreviation:  J Environ Pathol Toxicol     Publication Date:    1979 Jan-Feb
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801245     Medline TA:  J Environ Pathol Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  873-87     Citation Subset:  IM    
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MeSH Terms
Chloroform / analysis*
Epidemiologic Methods
Neoplasms / mortality*
Regression Analysis
Statistics as Topic
United States
Water Pollutants / analysis*
Water Pollutants, Chemical / analysis*
Water Supply / analysis*
Reg. No./Substance:
0/Water Pollutants; 0/Water Pollutants, Chemical; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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