Document Detail

Association between changes in N-terminal pro-brain natriuretic peptide levels and changes in left ventricular mass index in stable hemodialysis patients.
MedLine Citation:
PMID:  18815449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Left ventricular (LV) hypertrophy is a powerful predictor of mortality in dialysis patients. Serial measurements of LV mass provide prognostic information. We evaluated the association between changes in biomarkers and changes in LV mass index (LVMI) in hemodialysis (HD) patients. METHODS: This was a prospective study of 21 stable HD patients with preserved LV ejection fraction (> or =50%). Echocardiography and measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP) and cardiac troponin T were performed on the same day and repeated 6 and 12 months later. RESULTS: At baseline, the NT-proBNP and BNP levels correlated with LVMI. Percent changes in LVMI were positively associated with those in log-transformed NT-proBNP levels during both the first (baseline vs. month 6, r = 0.78, p < 0.001) and the second 6 months (months 6 vs. 12, r = 0.73, p < 0.001). Among the 3 biomarkers, NT-proBNP was the only one that was related to changes in LVMI by multivariate correlation analysis, including age, sex, blood pressure, predialysis weight and use of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. CONCLUSION: Our results show that changes in LVMI are closely correlated with variation in NT-proBNP levels in HD patients. These data have significant implications for the application of NT-proBNP as a biomarker for assessing changes in LVMI in HD patients.
So Yeon Choi; Jung Eun Lee; Eun Hee Jang; Min-Ok Kim; Hyunjeong Baek; Chang Seok Ki; Seung Woo Park; Dae Joong Kim; Woo Seong Huh; Ha Young Oh; Yoon-Goo Kim
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-09-25
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  110     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-06     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c93-100     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Medicine and Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.
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MeSH Terms
Hypertrophy, Left Ventricular / blood,  complications*,  diagnosis*
Kidney Failure / blood*,  complications,  diagnosis,  prevention & control*
Middle Aged
Natriuretic Peptide, Brain / blood*
Organ Size
Peptide Fragments / blood*
Renal Dialysis*
Ventricular Dysfunction, Left / blood,  complications*,  diagnosis*
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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