Document Detail


Association between cerebral metabolism and Rey-Osterrieth Complex Figure Test performance in Alzheimer's disease.
MedLine Citation:
PMID:  23387510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The copy condition of the Rey-Osterrieth Complex Figure (ROCF) is sensitive to Alzheimer's disease (AD) pathology, but its neural correlates remain unclear. We used fluorodeoxyglucose positron emission tomography (FDG-PET) to elucidate this association in 77 patients with probable AD. We observed a correlation between ROCF and metabolic rate of bilateral temporal-parietal cortex and occipital lobe, and right frontal lobe. Global and local elements of the ROCF correlated with metabolic rate of these same regions. The copy approach correlated with right lateral temporal cortex. The ROCF appears reflective of posterior temporal-parietal cortex functioning, highlighting the role of visuospatial processing in constructional abilities in AD.
Authors:
Rebecca J Melrose; Dylan Harwood; Theresa Khoo; Mark Mandelkern; David L Sultzer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-07
Journal Detail:
Title:  Journal of clinical and experimental neuropsychology     Volume:  35     ISSN:  1744-411X     ISO Abbreviation:  J Clin Exp Neuropsychol     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-14     Completed Date:  2013-08-26     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  8502170     Medline TA:  J Clin Exp Neuropsychol     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-58     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / metabolism*,  psychology*,  radionuclide imaging
Brain / metabolism*,  radionuclide imaging
Brain Mapping
Female
Functional Neuroimaging
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Neuropsychological Tests
Grant Support
ID/Acronym/Agency:
R01 MH056031/MH/NIMH NIH HHS; R01 MH56031/MH/NIMH NIH HHS
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