Document Detail

Association between cardiovascular reactivity to stress and hypertension or behavior.
MedLine Citation:
PMID:  1973873     Owner:  NLM     Status:  MEDLINE    
The spontaneously hypertensive rat (SHR) exhibits increased cardiovascular reactivity (CVR) to environmental stress and behavioral hyperactivity relative to the Wistar-Kyoto rat (WKY). This study sought to determine whether enhanced CVR to stress in the SHR is related to hypertension or to behavioral hyperactivity. By breeding SHR with WKY, followed by inbreeding, E. D. Hendley has developed two strains in which the hypertensive trait seems to be separated from the hyperactivity trait: the Wistar-Kyoto hypertensive (WK-HT) and the Wistar-Kyoto hyperactive (WK-HA) strains. Male SHR, WKY, WK-HT, and WK-HA rats were implanted with intravascular catheters and Doppler flow-velocity probes to record arterial pressure, heart rate (HR), and changes in regional vascular resistances. Five days after surgery, the rats were subjected to air-jet stress and pharmacological interventions. The hyperactive strains (SHR and WK-HA) exhibited enhanced pressor, renal, and mesenteric responses to stress, and higher HRs under all conditions, even after autonomic blockade. Both hypertension and hyperactivity were associated with reduced baroreceptor sensitivity. These data indicate that CVR to stress is related to behavioral traits.
S Knardahl; E D Hendley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  259     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H248-57     Citation Subset:  IM    
Division for Environmental Toxicology, Norwegian Defense Research Establishment, Kjeller.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Behavior, Animal / drug effects,  physiology*
Blood Pressure / drug effects,  physiology
Captopril / pharmacology
Cardiovascular Physiological Phenomena*
Cardiovascular System / ultrastructure
Hypertension / physiopathology*
Pressoreceptors / drug effects,  physiology
Propanolamines / pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Adrenergic, beta / drug effects,  physiology
Renin-Angiotensin System / drug effects,  physiology
Stress, Physiological / physiopathology*
Vascular Resistance / drug effects,  physiology
Vasoconstriction / drug effects,  physiology
Vasodilation / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 62571-86-2/Captopril; 72795-19-8/ICI 118551

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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