| Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China. | |
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MedLine Citation:
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PMID: 20833111 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this study was to investigate the association between carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) and the HLA-B*1502 allele among patients from central China. Eight patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), 28 with mild maculopapular eruptions (MPEs), 50 CBZ-tolerant controls, and 71 healthy volunteers were recruited. HLA genotyping was performed using the polymerase chain reaction sequence-based typing (SBT) method. As a result, the HLA-B*1502 allele was observed at the following rates: (1) 100% (8/8) among those with CBZ-induced SJS/TEN, (2) 10.7% (3/28) among those with CBZ-induced MPEs; (3) 8.0% (4/50) among CBZ-tolerant controls; (4) 8.5% (6/71) among healthy volunteers. The eight patients with SJS/TEN positive for the HLA-B*1502 allele had an odds ratio (OR) of 184 compared with CBZ-tolerant controls. There was no significant difference in frequency between patients with MPEs and CBZ-tolerant controls (P>0.05). Thus, CBZ-induced SJS/TEN, but not MPEs, is strongly associated with HLA-B*1502. Testing for HLA-B*1502 should be recommended for patients from central China prior to initial CBZ treatment. |
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Authors:
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X T Wu; F Y Hu; D M An; B Yan; X Jiang; P Kwan; H Stefan; D Zhou |
Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 19 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 405-8 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Epilepsy Center, Department of Neurology, University Hospital of Erlangen-Nuremberg, Erlangen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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