| Association between calcium intake and colorectal neoplasia in Puerto Rican Hispanics. | |
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MedLine Citation:
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PMID: 21866684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of this cross-sectional study, a total of 433 subjects were recruited from surgery and gastroenterology clinics at the University of Puerto Rico. Calcium intake was estimated using a food frequency questionnaire (FFQ) of calcium rich foods. Socio-demographics, health history and colonoscopy results were obtained from the primary study. Chi square and odds ratios (OR) for colorectal neoplasia (adenomas and/ or adenocarcinoma) were calculated for total calcium, dietary calcium and for calcium supplement use. In total, 312 (72%) from 433 participants completed the FFQ and had available colonoscopy results; from these, 196 (62.5%) were free of neoplasia and 117 (37.5%) had colorectal neoplasia. Colorectal neoplasia subjects were older, a lower proportion were females and less educated than those without neoplasia (p < 0.01). Total calcium intake (median 1180 mg/d) was greater in those free of neoplasia compared to colorectal neoplasia subjects (median 1036 mg/d; p<0.05). A high total calcium intake and the use of calcium supplements significantly reduced the OR (crude and age adjusted) for colorectal neoplasia; although these associations lost statistical significance after additionally adjusting for gender and educational level. In conclusion, a high calcium intake and the use of calcium supplements may be protective against colorectal neoplasia, although a greater sample may be required to observe significant associations in a multivariate model. |
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Authors:
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Cristina Palacios; Maritza Lopez; Ana Patricia Ortiz; Marcia Cruz Correa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Archivos latinoamericanos de nutrición Volume: 60 ISSN: 0004-0622 ISO Abbreviation: Arch Latinoam Nutr Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-08-26 Completed Date: 2011-11-29 Revised Date: 2011-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0067507 Medline TA: Arch Latinoam Nutr Country: Venezuela |
Other Details:
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Languages: eng Pagination: 348-54 Citation Subset: IM |
Affiliation:
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University of Puerto Rico, University of North Texas, University of Puerto Rico, San Juan. Puerto Rico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Calcium, Dietary / administration & dosage* Colonoscopy Colorectal Neoplasms / diagnosis, epidemiology*, prevention & control Cross-Sectional Studies Diet Records Dietary Supplements* Female Humans Male Middle Aged Puerto Rico / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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G12RR-03051/RR/NCRR NIH HHS; K22CA115913/CA/NCI NIH HHS; U50-CCU325128-01-01//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium, Dietary |
| Comments/Corrections | |
Erratum In:
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Arch Latinoam Nutr. 2011 Mar;61(1):106 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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