Document Detail

Association between calcium intake and colorectal neoplasia in Puerto Rican Hispanics.
MedLine Citation:
PMID:  21866684     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of this cross-sectional study, a total of 433 subjects were recruited from surgery and gastroenterology clinics at the University of Puerto Rico. Calcium intake was estimated using a food frequency questionnaire (FFQ) of calcium rich foods. Socio-demographics, health history and colonoscopy results were obtained from the primary study. Chi square and odds ratios (OR) for colorectal neoplasia (adenomas and/ or adenocarcinoma) were calculated for total calcium, dietary calcium and for calcium supplement use. In total, 312 (72%) from 433 participants completed the FFQ and had available colonoscopy results; from these, 196 (62.5%) were free of neoplasia and 117 (37.5%) had colorectal neoplasia. Colorectal neoplasia subjects were older, a lower proportion were females and less educated than those without neoplasia (p < 0.01). Total calcium intake (median 1180 mg/d) was greater in those free of neoplasia compared to colorectal neoplasia subjects (median 1036 mg/d; p<0.05). A high total calcium intake and the use of calcium supplements significantly reduced the OR (crude and age adjusted) for colorectal neoplasia; although these associations lost statistical significance after additionally adjusting for gender and educational level. In conclusion, a high calcium intake and the use of calcium supplements may be protective against colorectal neoplasia, although a greater sample may be required to observe significant associations in a multivariate model.
Cristina Palacios; Maritza Lopez; Ana Patricia Ortiz; Marcia Cruz Correa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archivos latinoamericanos de nutrición     Volume:  60     ISSN:  0004-0622     ISO Abbreviation:  Arch Latinoam Nutr     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-08-26     Completed Date:  2011-11-29     Revised Date:  2011-12-19    
Medline Journal Info:
Nlm Unique ID:  0067507     Medline TA:  Arch Latinoam Nutr     Country:  Venezuela    
Other Details:
Languages:  eng     Pagination:  348-54     Citation Subset:  IM    
University of Puerto Rico, University of North Texas, University of Puerto Rico, San Juan. Puerto Rico.
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MeSH Terms
Calcium, Dietary / administration & dosage*
Colorectal Neoplasms / diagnosis,  epidemiology*,  prevention & control
Cross-Sectional Studies
Diet Records
Dietary Supplements*
Middle Aged
Puerto Rico / epidemiology
Grant Support
G12RR-03051/RR/NCRR NIH HHS; K22CA115913/CA/NCI NIH HHS; U50-CCU325128-01-01//PHS HHS
Reg. No./Substance:
0/Calcium, Dietary
Erratum In:
Arch Latinoam Nutr. 2011 Mar;61(1):106

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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