| Association between cadmium concentration in rice and mortality in the Jinzu River basin, Japan. | |
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MedLine Citation:
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PMID: 11376862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A follow-up survey on 2101 inhabitants (1566 men, 535 women), who participated in a 1967 health survey and had resided in their present rural community since birth was conducted to determine the influence of environmental cadmium exposure on the mortality of the general population in the Jinzu River basin. The survey was conducted over 6128 days from August 1, 1967 to May 10, 1984. The rural communities were divided into two groups, one with a cadmium concentration in rice of < 0.30 ppm and the other > or = 0.30 ppm. The influence of cadmium concentration in rice on mortality was analyzed using SMRs and a Cox's proportional hazards model. In both sexes, SMRs tended to be greater in the > or = 0.3 ppm group as compared to < 0.3 ppm group. The Cox hazard ratios for males and females in the > or = 0.30 ppm group, to those in the < 0.30 ppm group, were 1.42 and 1.10, respectively (significant in the men). Since the mean cadmium concentration in rice in each rural community was closely related to the development of renal injury, in regions with high cadmium concentrations in rice, the development of renal injury induced by cadmium is believed to be the factor underlying the increased mortality observed. |
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Authors:
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T Ishihara; E Kobayashi; Y Okubo; Y Suwazono; T Kido; M Nishijyo; H Nakagawa; K Nogawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology Volume: 163 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-06-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: Ireland |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Department of Hygiene, Chiba University School of Medicine, 1-8-1 Inohana, Chuohku, 260-8670, Chiba, Japan. etuko@med.m.chiba-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cadmium / analysis Cadmium Poisoning / mortality* Dose-Response Relationship, Drug Environmental Exposure / adverse effects* Environmental Pollutants / adverse effects* Female Follow-Up Studies Food Contamination / analysis* Humans Male Middle Aged Oryza sativa* Proportional Hazards Models Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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