| Association between bone scintigraphy and serum levels of tumor markers in the detection of bone disease in breast cancer patients. | |
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MedLine Citation:
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PMID: 18067209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the diagnostic value of bone scan in association with measurements of serum CEA, CA 15-3 and TPA levels in breast cancer (BC) patients. PATIENTS AND METHODS: From September 1999 to January 2005, 89 women with BC who had undergone bone scintigraphy as part of their follow-up were retrospectively evaluated. Serum tumor markers levels were compared with the results of bone scintigraphy. Patients with positive bone scans were divided into 3 groups: group 1: 1-3, group 2: 4-5, group 3: >5 bone lesions. Serum CEA, CA 15-3 and TPA levels of 7 ng/ml, 35 U/ml and 90 U/I, respectively, were adopted as the upper limit of normal. RESULTS: Serum CA 15-3 was significantly higher in patients with a positive bone scan (p=0.017). For CEA and TPA, no significant difference was found between patients with and without bone metastases. Twenty-five of 70 patients (36%) with normal CEA had bone metastases. Four of 50 (8%) patients with normal CA 15-3 and 15 of 51 (29%) patients with normal TPA had a positive bone scan. The combination of CA 15-3 with TPA showed 100% sensitivity in detecting bone metastases in all patient subgroups. In all 42 patients without bone metastases, CA 15-3 and/or TPA levels were normal. CONCLUSION: CA 15-3 but not CEA or TPA is sensitive and specific for the correct determination of bone scintigraphy. CA 15-3 plus TPA represent the best combination in association with bone scanning. However, due to frequent false negative results of all tumor markers, it is not recommended to reject a bone scan on the basis of tumor markers levels. |
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Authors:
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A Zissimopoulos; D Matthaios; E Matthaiou; E Mantadakis; I Karaitianos |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of B.U.ON. : official journal of the Balkan Union of Oncology Volume: 12 ISSN: 1107-0625 ISO Abbreviation: J BUON Publication Date: 2007 Oct-Dec |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883428 Medline TA: J BUON Country: Greece |
Other Details:
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Languages: eng Pagination: 505-11 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece. azissim@yahoo.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bone Neoplasms / diagnosis, radionuclide imaging*, secondary* Breast Neoplasms / pathology* Female Humans Middle Aged Retrospective Studies Sensitivity and Specificity Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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