| Association between body mass and mortality in maintenance hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 20649761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A total of 959 Taiwanese patients undergoing maintenance hemodialysis-102 underweight (BMI < 18.5 kg/m(2)), 492 normal weight (BMI 18.5-22.9 kg/m(2)), 187 overweight (BMI 23.0-24.9 kg/m(2)), and 178 obese (BMI >or= 25 kg/m(2)) were recruited into this three-year, multicenter longitudinal study. It was found initially that the underweight group had more females, longer hemodialysis durations, less use of a biocompatible membrane (BCM) dialyzer, higher erythropoietin doses and Kt/V(urea), and lower white blood cell counts, hemoglobin, serum creatinine and phosphate, and high sensitivity C-reactive protein (hsCRP) than other groups (P < 0.001). Furthermore, a chi(2)-test demonstrated that underweight patients had poorer nutrition (P = 0.023), but less systemic inflammation (P < 0.001) than other groups. A stepwise multiple linear regression analysis established that age, sex, diabetes mellitus, hemodialysis duration, use of BCM dialyzer, Kt/V(urea), creatinine, high-density lipoprotein cholesterol, and hsCRP were significant risk factors associated with BMI (P < 0.001-0.002). After three years, 149 (15.5%) patients had died, including 22 of 102 (21.6%) underweight patients, 64 of 492 (13.0%) normal weight patients, 38 of 187 (20.3%) overweight patients, and 25 of 178 (15.5%) obese patients. The primary causes of mortality were cardiovascular (52.3%) and infection (39.6%). A multivariate Cox regression analysis revealed that age, diabetes mellitus, BMI, albumin, hsCRP, and cardiothoracic ratio were significant risk factors associated with all-cause mortality over three years (P < 0.001-0.022). Finally, Kaplan-Meier analysis confirmed that underweight patients suffer higher mortality than other groups (Log rank, P = 0.0392); therefore, the data have demonstrated a survival disadvantage of low BMI in Taiwanese patients undergoing maintenance hemodialysis. |
| | |
Authors:
|
Tzung-Hai Yen; Ja-Liang Lin; Dan-Tzu Lin-Tan; Ching-Wei Hsu |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 14 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
|
Languages: eng Pagination: 400-8 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan. m19570@adm.cgmh.org.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Body Mass Index* Cardiovascular Diseases / etiology, mortality Female Humans Infection / etiology, mortality Kaplan-Meiers Estimate Kidney Failure, Chronic / therapy* Linear Models Longitudinal Studies Male Middle Aged Multivariate Analysis Proportional Hazards Models Prospective Studies Renal Dialysis / mortality* Risk Factors Taiwan Thinness / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Double filtration plasmapheresis in antibody-incompatible kidney transplantation.
Next Document: Long-term natural history of acquired cystic disease of the kidney.