Document Detail

Association between birth weight in preterm neonates and the BclI polymorphism of the glucocorticoid receptor gene.
MedLine Citation:
PMID:  18595687     Owner:  NLM     Status:  MEDLINE    
Endogenous and exogenous glucocorticoids influence fetal growth and development, and maternal administration of synthetic glucocorticoids may decrease the risk of perinatal morbidity including lung disease in preterm neonates. Because polymorphisms of the glucocorticoid receptor gene are known to influence the sensitivity to glucocorticoids, in the present study we examined whether any associations could exist among the BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene and gestational age, birth weight and/or perinatal morbidity of 125 preterm neonates born at 28-35 weeks' gestation with (n=57) or without maternal dexamethasone treatment (n=68). The prevalence of the three polymorphisms in the whole group of preterm infants was similar to that reported in healthy adult Hungarian population. However, we found that the BclI polymorphism significantly associated with higher birth weight adjusted for the gestational age (p=0.004, ANOVA analysis). None of the three polymorphisms showed an association with perinatal morbidities, including necrotizing enterocolitis, intraventricular hemorrhagia, patent ductus arteriosus, respiratory distress syndrome, bronchopulmonary dysplasia and sepsis in the two groups of preterm neonates with and without maternal dexamethasone treatment. These results suggest that the BclI polymorphism of the glucocorticoid receptor gene may have an impact on gestational age-adjusted birth weight, but it does not influence perinatal morbidities of preterm neonates.
Rita Bertalan; Attila Patocs; Barna Vasarhelyi; Andras Treszl; Ibolya Varga; Eva Szabo; Judit Tamas; Judit Toke; Belema Boyle; Andras Nobilis; Janos Rigo; Karoly Racz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  111     ISSN:  0960-0760     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-4     Citation Subset:  IM    
2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 1088 Budapest, Szentkiralyi 46, Hungary.
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MeSH Terms
Birth Weight / genetics*
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature*
Polymorphism, Genetic*
Premature Birth / genetics*
Receptors, Glucocorticoid / genetics*
Reg. No./Substance:
0/Receptors, Glucocorticoid

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