Document Detail


Association between autoimmune pancreatitis and systemic autoimmune diseases.
MedLine Citation:
PMID:  22690073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the association between autoimmune pancreatitis (AIP) and systemic autoimmune diseases (SAIDs) by measurement of serum immunoglobulin G4 (IgG4).
METHODS: The serum level of IgG4 was measured in 61 patients with SAIDs of different types who had not yet participated in glucocorticosteroid treatment. Patients with an elevated IgG4 level were examined by abdominal ultrasonography (US) and, in some cases, by computer tomography (CT).
RESULTS: Elevated serum IgG4 levels (919 ± 996 mg/L) were detected in 17 (28%) of the 61 SAID patients. 10 patients had Sjögren's syndrome (SS) (IgG4: 590 ± 232 mg/L), 2 of them in association with Hashimoto's thyroiditis, and 7 patients (IgG4: 1388 ± 985.5 mg/L) had systemic lupus erythematosus (SLE). The IgG4 level in the SLE patients and that in patients with SS were not significantly different from that in AIP patients (783 ± 522 mg/L). Abdominal US and CT did not reveal any characteristic features of AIP among the SAID patients with an elevated IgG4 level.
CONCLUSION: The serum IgG4 level may be elevated in SAIDs without the presence of AIP. The determination of serum IgG4 does not seem to be suitable for the differentiation between IgG4-related diseases and SAIDs.
Authors:
Viktória Terzin; Imre Földesi; László Kovács; Gyula Pokorny; Tibor Wittmann; László Czakó
Related Documents :
22617153 - The laennec staging system for histological sub-classification of cirrhosis is useful f...
22318813 - Sequential involvement of the nervous system in subacute combined degeneration.
24934863 - Third-space fluid distribution of pemetrexed in non-small cell lung cancer patients.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-10-29     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2649-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Autoimmune Diseases / blood,  complications*,  immunology*
Female
Hashimoto Disease / complications,  immunology
Humans
Immunoglobulin G / blood*
Lupus Erythematosus, Systemic / complications,  immunology
Male
Middle Aged
Pancreatitis / blood,  complications*,  immunology*
Pilot Projects
Sjogren's Syndrome / complications,  immunology
Tomography, X-Ray Computed / methods
Ultrasonography / methods
Chemical
Reg. No./Substance:
0/Immunoglobulin G
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchyma...
Next Document:  Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carc...