Document Detail

Association between arterial stiffness and peritoneal small solute transport rate.
MedLine Citation:
PMID:  18471172     Owner:  NLM     Status:  MEDLINE    
While cardiovascular disease accounts for 40-50% of the mortality in dialysis patients, and while a high peritoneal transport in continuous ambulatory peritoneal dialysis (CAPD) is an independent predictor of outcome, it is unclear if there are any links. Aortic stiffness has become established as a cardiovascular risk factor. We thus studied pulse wave velocity (PWV) in CAPD patients to explore the possible link between peritoneal small solute transport and aortic stiffness. CAPD patients (n = 76, 27 M/49 F) in our center were included in the present study. Aortic stiffness was assessed by brachial pulse pressure (PP) and carotid-femoral PWV. Patients' peritoneal small solute transport rate was assessed by D/P(cr) at 4 h. Extracellular water over total body water (E/T ratio) was assessed by means of bioimpedance analysis. C-reactive protein was also measured. Carotid-femoral PWV was positively associated with patients' age (r = 0.555; P < 0.01), time on peritoneal dialysis (r = 0.332; P < 0.01), diabetic status (r = 0.319; P < 0.01), D/P(cr) (r = 0.241; P < 0.05), PP (r = 0.475; P < 0.01), and E/T (r = 0.606; P < 0.01). In a multivariate regression analysis, carotid-femoral PWV was independently determined by E/T (P < 0.01), PP (P < 0.01), age (P < 0.01), and D/P(cr) (P < 0.05). D/P(cr), in addition to E/T, age, and PP, was an independent predictor of elevated carotid-femoral PWV in CAPD patients, suggesting that there might be a link between high aortic stiffness and increased peritoneal small solute transport rate.
Xing-wei Zhe; Xin-kui Tian; Wei Chen; Li-juan Guo; Yue Gu; Hui-min Chen; Li-jun Tang; Tao Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  32     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-9     Citation Subset:  IM    
Division of Nephrology, Peking University Third Hospital, Beijing, China.
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MeSH Terms
Age Factors
Arteriosclerosis / physiopathology*
Blood Pressure*
Body Composition
Body Water / physiology
C-Reactive Protein / analysis
Carotid Arteries / physiopathology
Creatinine / blood
Dialysis Solutions
Electric Impedance
Extracellular Fluid / physiology
Femoral Artery / physiopathology
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Regression Analysis
Reg. No./Substance:
0/Dialysis Solutions; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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