Document Detail

Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.
MedLine Citation:
PMID:  12881819     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the value of apolipoprotein E4 (APOE*E4) allele in predicting discharge impairment and disability in ischemic stroke patients after acute rehabilitation.
DESIGN: Prospective study comparing results of rehabilitation in patients with different APOE genotypes.
SETTING: Acute neurologic rehabilitation department in Israel.
PARTICIPANTS: One hundred one consecutive patients 75 years old or less with a first ischemic stroke.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURE: Impairment, as measured by the National Institutes of Health Stroke Scale (NIHSS), and disability, as assessed with the FIM trade mark instrument.
RESULTS: On admission, there was no significant difference in the FIM or NIHSS measurements between the apo E4 group and other patients, but the prevalence of aphasia was 2.07 times more frequent in those with the APOE*E4 genotype (95% confidence interval, 0.98-4.4). A logistic regression model demonstrated that score measurements on admission were highly predictive of the NIHSS score at discharge (receiver operator curve=96.1%), whereas the presence of the APOE*E4 genotype did not add significantly to the model in predicting poorer rehabilitation treatment outcome as measured by the FIM or the NIHSS.
CONCLUSIONS: The presence of the apo E4 allele did not predict a poorer outcome of rehabilitation treatment after ischemic stroke, but it was associated with an increased prevalence of aphasia. Further studies are warranted to confirm this association.
Iuly Treger; Paul Froom; Haim Ring; Gideon Friedman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  84     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-25     Completed Date:  2003-08-12     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  973-6     Citation Subset:  AIM; IM    
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MeSH Terms
Activities of Daily Living
Acute Disease
Analysis of Variance
Aphasia / etiology
Apolipoprotein E4
Apolipoproteins E / blood*,  genetics
Brain Ischemia / complications*
Disability Evaluation
Hospitalization* / statistics & numerical data
Logistic Models
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic / genetics
Predictive Value of Tests
Prospective Studies
Rehabilitation Centers*
Severity of Illness Index
Single-Blind Method
Stroke / blood*,  etiology,  rehabilitation*
Treatment Outcome
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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