| Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals. | |
| | |
MedLine Citation:
|
PMID: 19377787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphism. APOE gene polymorphisms were similar in both groups, but the epsilon4/epsilon4 genotype (6%) was present only in controls. The patients had reduced levels (mean +/- SD) of total cholesterol and low-density lipoprotein cholesterol fraction (180.4 +/- 49.5 and 116.1 +/- 43.1 mg/dL, respectively) compared to controls (204.2 +/- 55.6, P = 0.135 and 134.7 +/- 50.8 mg/dL; P = 0.330, respectively) indicating that they were not statistically significant after the Bonferroni correction. The APOE*4 allele was associated with lower levels of total cholesterol, low- and high-density lipoprotein cholesterol fraction and increased levels of very low-density lipoprotein cholesterol fraction and triglycerides only among patients (P = 0.014). There was a positive correlation between the altered lipid profile and increased body mass indexes in both groups (P < 0.010). Moreover, a higher rate of hypertension and overweight was observed in controls (P < 0.002). In conclusion, the presence of the epsilon4/epsilon4 genotype only in controls may be due to a protective effect against CRC. Lower lipid profile values among patients, even those on lipid-rich diets associated with the APOE*4 allele, suggest alterations in the lipid synthesis and metabolism pathways in CRC. |
| | |
Authors:
|
D R S Souza; M A Nakazone; M A S Pinhel; R M Alvares; A C Monaco; A Pinheiro; C F D C Barros; P M Cury; G S Cunrath; J G Netinho |
Related Documents
:
|
3921727 - The effect of moderate alcohol intake on serum apolipoproteins a-i and a-ii. a controll... 6584917 - Metabolism of apolipoproteins b-48 and b-100 of triglyceride-rich lipoproteins in norma... 16458317 - Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in apoe k... 9541497 - Phenotype-dependent differences in apolipoprotein e metabolism and in cholesterol homeo... 22117667 - How much of racial/ethnic disparities in dietary intakes, exercise, and weight status c... 402277 - Cholesterol metabolism in papua new guineans. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 42 ISSN: 1414-431X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-20 Completed Date: 2009-08-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
|
Languages: eng Pagination: 397-403 Citation Subset: IM |
Affiliation:
|
Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Apolipoprotein E2 / genetics* Apolipoprotein E4 / genetics* Brazil Case-Control Studies Colorectal Neoplasms / blood, genetics* Female Gene Frequency Genetic Predisposition to Disease / genetics Genotype Humans Lipids / blood* Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic / genetics Polymorphism, Restriction Fragment Length Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoprotein E2; 0/Apolipoprotein E4; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early hemodynamics and metabolic changes after total abdominal evisceration for experimental multivi...
Next Document: Effect of carbohydrate availability on time to exhaustion in exercise performed at two different int...