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Association between aortic calcification and stable obstructive coronary artery disease.
MedLine Citation:
PMID:  21078528     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Coronary artery calcification (CAC) is correlated with aortic calcification (AC) and predicts coronary atherosclerosis as well as obstructive coronary artery disease (OCAD). This study aims to investigate whether AC predicts OCAD independent of CAC and its incremental value in predicting OCAD with CAC.
METHODS: Among the consecutive patients who underwent 64-slice multidetector CT (MDCT), we enrolled 120 stable OCAD (luminal narrowing ≥50%) patients and 120 controls without OCAD, matched for cardiovascular risk factors. CAC, thoracic AC, and OCAD were determined by MDCT.
RESULTS: The prevalence of AC and CAC were significantly higher in OCAD patients than in controls (64% vs. 48%, p=0.019; 57% vs. 32%, p<0.001, respectively). There is a significant correlation between AC and CAC scores in the overall study population (r=0.528, p<0.001). In univariate analysis, the odds ratios (ORs) of AC and CAC in predicting OCAD were 1.91 (95% CI, 1.14-3.21) and 2.82 (95% CI, 1.67-4.78), respectively. When an adjustment was made for each other, AC did not maintain a significant association with OCAD, whereas CAC persisted the association (OR, 2.52; 95% CI, 1.42-4.47). Both AC and CAC present as compared to both absent was found to be a more potent predictor for OCAD (OR, 3.37; 95% CI 1.78-6.36, p<0.001) than CAC alone.
CONCLUSIONS: The presence of AC was associated with stable OCAD independently from cardiovascular risk factors, but the association seemed to be based on the close correlation between AC and CAC. However, AC might have an incremental value with CAC for predicting OCAD.
Eung Ju Kim; Hwan Seok Yong; Hong Seog Seo; Sung Yoon Lim; Sun Won Kim; Mi-Na Kim; Yun Kyung Kim; Kanhaiya L Poddar; Sureshkumar Ramasamy; Jin Oh Na; Cheol Ung Choi; Hong Euy Lim; Jin Won Kim; Seong Hwan Kim; Eun Mi Lee; Seung-Woon Rha; Chang Gyu Park; Dong Joo Oh
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Publication Detail:
Type:  Journal Article     Date:  2010-11-13
Journal Detail:
Title:  International journal of cardiology     Volume:  153     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  192-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Ireland Ltd.
Cardiovascular Center, Division of Cardiology, Department of Internal Medicine, Seoul, South Korea.
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