Document Detail

Association between anxiety disorder and the extent of ischemia observed in cardiac syndrome X.
MedLine Citation:
PMID:  19156475     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A possible link between the heart and brain has been reported for cardiac syndrome X. Anxiety disorder could be a pathophysiological mechanism for this cardiac chest pain. To the authors' knowledge, a quantitative analysis correlating anxiety with the extent of ischemia has not been done. METHODS AND RESULTS: In this pilot study, we evaluated 20 patients with typical chest pain and completely normal coronary angiograms. These patients were screened with the State Scale and Trait Scale of the State-Trait Anxiety Inventory (STAI). All patients underwent myocardial perfusion scintigraphic imaging. The scintigrams were scored by three experienced readers having no knowledge of the STAI screening results. Patients with a low trait anxiety had significantly less ischemic segments on the myocardial perfusion imaging than patients with a high trait anxiety (1.8 +/- 1.9 vs 3.5 +/- 0.6, P < .05). For state anxiety, no significant differences could be found. CONCLUSION: Cardiac syndrome X patients with high trait anxiety are at risk of having more ischemia.
I A C Vermeltfoort; P G H M Raijmakers; D A M Odekerken; A F M Kuijper; A Zwijnenburg; G J J Teule
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Publication Detail:
Type:  Journal Article     Date:  2009-01-22
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  16     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, de Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands.
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MeSH Terms
Anxiety / complications*,  radionuclide imaging*
Chest Pain
Microvascular Angina / complications*,  radionuclide imaging*
Middle Aged
Myocardial Ischemia / complications*,  radionuclide imaging*
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon / methods*

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