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Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population: a meta-analysis.
MedLine Citation:
PMID:  21881578     Owner:  NLM     Status:  Publisher    
No consensus has been reached on the association between the angiotensinogen gene polymorphism T174M and hypertension risk in the Chinese population. We conducted a meta-analysis to systematically pursue their possible association. Case-control studies in the Chinese and English publications were identified by searching the MEDLINE, EMBASE, CBM, CNKI, Wanfang and VIP databases. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. After this, we selected 16 studies that met the inclusion criteria. In total, the selected studies contributed a study population containing 3828 hypertensive patients and 3251 normotensive controls. We found no statistical association between the T174M polymorphism and hypertension risk in all subjects, in a Han Chinese subgroup or in non-Han Chinese minorities. However, a statistically significant association was observed between the T174M polymorphism and a hypertensive group (systolic blood pressure 160 mm Hg and/or diastolic blood pressure 95 mm Hg) in the dominant genetic model (MM+MT vs. TT: P=0.03, odds ratio=1.71, 95% confidence interval 1.07-2.74, P(heterogeneity)=0.27, I(2)=24%, fixed-effects model). No evidence of publication bias was observed. More studies, especially studies stratified for different stages of hypertension, should be performed in the future to fully examine this question. Studies investigating gene-gene interactions, gene-environment interactions, as well as their mutual interactions will also be important.Hypertension Research advance online publication, 1 September 2011; doi:10.1038/hr.2011.141.
Wei Gu; Ya Liu; Zuoguang Wang; Kuo Liu; Yuqing Lou; Qiuli Niu; Hao Wang; Jinghua Liu; Shaojun Wen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-01
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
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