| Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 14736447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The aim of our study was to evaluate the relationship between aldosterone synthase gene polymorphism and cardiac dimensions in essential hypertension. BACKGROUND: Higher aldosterone synthase messenger ribonucleic acid levels in the human heart are accompanied by increased intracardiac aldosterone production, a phenomenon that is associated with cardiac fibrosis and hypertrophy. Recent evidence suggests that a polymorphism (-344C/T) in the promoter region of the aldosterone synthase gene is associated with increased constitutive aldosterone production. METHOD: Relationships between M-mode echocardiographic cardiac dimensions and aldosterone synthase -344C/T polymorphism were studied in 210 never-treated, middle-aged patients (age 41.6 +/- 1.4 years) affected by mild to moderate essential hypertension. Among these patients, 48 had the genotype -C344C, 97 had -C344T, and 65 had -T344T. Patients in the three groups were similar in terms of age, gender, body mass index, and blood pressure. RESULTS: Left ventricular (LV) mass and thickness were positively correlated with the number of T alleles: LV mass (CC, CT, and TT, respectively: 168 +/- 6.9, 179 +/- 5.2, and 193 +/- 6.9 g; p = 0.03), LV septal thickness (0.99 +/- 0.02, 1.03 +/- 0.02, and 11.08 +/- 0.03 cm, p = 0.04), PWT (0.93 +/- 0.03, 0.95 +/- 0.01, and 1.03 +/- 0.02 cm; p = 0.002), and relative wall thickness (38.3 +/- 1.2%, 38.8 +/- 0.8%, and 42.8 +/- 1.1%; p = 0.004). This trend was confirmed by linear regression, suggesting a "major gene" behavior for the T allele. Multiple regression analysis showed that this effect was independent of anthropometric and clinical factors, including adrenal aldosterone. CONCLUSIONS: Our data suggest that -344C/T polymorphism affects LV mass and thickness in essential hypertension, independent of adrenal aldosterone. A role for intracardiac aldosterone synthesis is hypothesized. |
| | |
Authors:
|
Paola Stella; Giada Bigatti; Laura Tizzoni; Cristina Barlassina; Chiara Lanzani; Giuseppe Bianchi; Daniele Cusi |
Related Documents
:
|
9443767 - Association between increased plasma levels of aldosterone and decreased systemic arter... 20651817 - Effect of sodium houttuyfonate on inhibiting ventricular remodeling induced by abdomina... 20083287 - Clinical outcome after laparoscopic adrenalectomy for primary hyperaldosteronism: the r... 3010707 - Humoral effects of long-term oral enalapril therapy. 17413097 - Is higher dairy consumption associated with lower body weight and fewer metabolic distu... 3485937 - Esmolol attenuates hemodynamic responses during fentanyl-pancuronium anesthesia for aor... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 43 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-22 Completed Date: 2004-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 265-70 Citation Subset: AIM; IM |
Affiliation:
|
Division of Nephrology, Dialysis and Hypertension, Graduate School of Nephrology, University "Vita e Salute" San Raffaele, Milan, Italy. paola.stella@hsr.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aldosterone Synthase / genetics* Female Fibrosis / genetics Heart Ventricles / pathology Humans Hypertension / complications, genetics* Hypertrophy, Left Ventricular / complications, genetics* Male Middle Aged Polymorphism, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
|
EC 1.14.15.4/Aldosterone Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of the physiologic significance of coronary disease with dipyridamole real-time myocardia...
Next Document: Transient constrictive pericarditis: causes and natural history.