Document Detail

Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-year follow-up study.
MedLine Citation:
PMID:  10826398     Owner:  NLM     Status:  MEDLINE    
Although it has been suggested that alcohol intake is related to hypertension, few long-term prospective studies have investigated this relationship. We therefore conducted a prospective study in male residents of a farming community in Japan to determine whether heavy drinking would predispose to the development of hypertension. A total of 325 normotensive (< 140/90 mm Hg) men were enrolled in 1977. Twelve years later, 93 (28.6%) subjects became hypertensive (defined as blood pressure > or = 140/90 mm Hg or use of antihypertensive medication). The probability of the development of hypertension in heavy drinkers predicted from a logistic regression equation was 44.6% (relative risk: 2.05 versus nondrinkers) after adjusting for age and body mass index (BMI). It was 36.2% (relative risk: 1.86 versus nondrinkers) after a further adjustment for systolic blood pressure at baseline. A high odds ratio of 2.39 for the development of hypertension with alcohol intake of < 46 g/day versus > or = 46 g/day at baseline was obtained even after adjustments for age, BMI, and confounding factors. We conclude that habitual heavy drinking of alcohol is a risk factor for the development of hypertension. This is the first report demonstrating a significant relationship between habitual alcohol intake and the development of hypertension in a long-term prospective study in Japan.
M Tsuruta; H Adachi; Y Hirai; Y Fujiura; T Imaizumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  13     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-12     Completed Date:  2000-09-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  482-7     Citation Subset:  IM    
The Third Department of Internal Medicine, and The Cardiovascular Research Institute, Kurume University School of Medicine, Japan.
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MeSH Terms
Alcohol Drinking / adverse effects*,  ethnology
Blood Pressure*
Body Mass Index
Cross-Sectional Studies
Follow-Up Studies
Hypertension / ethnology,  etiology*
Japan / epidemiology
Middle Aged
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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