| Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 20473008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: High levels of mean platelet volume (MPV) have been shown to be a predictor of poor clinical outcome among survivors of myocardial infarction. We evaluated the association between admission MPV and infarct-related artery (IRA) patency in patients treated with thrombolytic therapy for acute myocardial infarction (AMI). STUDY DESIGN: We retrospectively evaluated 133 consecutive patients with ST-elevation AMI, who received thrombolytic therapy within 12 hours of chest pain. Sixty-five patients received streptokinase and 68 patients received recombinant tissue-type plasminogen activator, based on the discretion of the physician. Blood samples were taken before thrombolytic therapy and MPV was measured. Coronary angiography was performed within a mean of two days after thrombolytic therapy and the flow in the IRA was assessed with the TIMI flow grade and corrected TIMI frame count (CTFC). RESULTS: After thrombolytic therapy, TIMI 3 flow was achieved in 62 patients (46.6%), whereas 71 patients (53.4%) had insufficient TIMI flow. Patients with insufficient TIMI flow had a significantly higher mean admission MPV (9.8+/-1.5 fl vs. 8.6+/-1.4 fl; p<0.001) and were more likely to have been given streptokinase (p=0.02). The two groups were similar with respect to the type of IRA and the number of diseased vessels (p>0.05). There was a weak correlation between MPV and CTFC (p=0.01). Multivariate analysis showed MPV (OR 1.871, 95% CI 1.402-2.498; p<0.001) and the type of thrombolytic agent (OR 2.915; 95% CI 1.333-6.374; p=0.007) as independent predictors of insufficient TIMI flow. The receiver operating characteristic analysis yielded a cutoff value of 8.885 fl for MPV to predict insufficient TIMI flow, with sensitivity and specificity being 70.4% and 66.1%, respectively. CONCLUSION: Our findings show that a higher admission MPV is associated with an increased risk for insufficient TIMI flow in the IRA after thrombolytic therapy for AMI. |
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Authors:
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Ayşe Saatci Yaşar; Emine Bilen; Isa Oner Yüksel; Uğur Arslantaş; Fatih Karakaş; Ozgür Kirbaş; Mehmet Bilge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır Volume: 38 ISSN: 1016-5169 ISO Abbreviation: Turk Kardiyol Dern Ars Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426239 Medline TA: Turk Kardiyol Dern Ars Country: Turkey |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Atatürk Education and Research Hospital, Ankara, Turkey. drasaatciyasar@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Angiography Coronary Vessels / physiopathology* Humans Myocardial Infarction / blood, drug therapy* Patient Admission Platelet Count* Streptokinase / therapeutic use* Thrombolytic Therapy / methods* Tissue Plasminogen Activator / therapeutic use* Vascular Patency / physiology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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