| Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia. | |
| | |
MedLine Citation:
|
PMID: 18226506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI) has been reported in schizophrenia, but not consistently replicated. We investigated the prevalence and anterior-posterior length of the AI in 62 schizophrenia patients (32 males, 30 females) and 63 healthy controls (35 males, 28 females) using magnetic resonance imaging. We also explored the relation between the AI and volumetric measurements for the third ventricle, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), superior temporal sub-regions, and frontal lobe regions (prefrontal area and anterior cingulate gyrus). The AI was absent in 24.2% (15/62) of the schizophrenia patients and in 9.5% (6/63) of the controls, showing a significant group difference. For the length of the AI, schizophrenia patients had a shorter AI than controls, and males had a shorter AI than females. The subjects without an AI had a significantly larger third ventricle and smaller parahippocampal gyrus than the subjects with an AI for both groups. We found a significant diagnosis-by-AI interaction for the amygdala. The schizophrenia patients without an AI had a smaller bilateral amygdala than those with an AI, whereas the AI was not associated with the volume of the amygdala in the control subjects. These findings suggest that the absence of AI in schizophrenia could be a marker of developmental abnormalities in the neural network including the thalamus and connected amygdaloid regions, which may play an important role in the pathogenesis of schizophrenia. |
| | |
Authors:
|
Tsutomu Takahashi; Michio Suzuki; Kazue Nakamura; Ryoichiro Tanino; Shi-Yu Zhou; Hirofumi Hagino; Lisha Niu; Yasuhiro Kawasaki; Hikaru Seto; Masayoshi Kurachi |
Related Documents
:
|
12363386 - Decreased calcium-dependent constitutive nitric oxide synthase (cnos) activity in prefr... 22308086 - Improved screening for silent atrial fibrillation after ischaemic stroke. 17316556 - Metacognitive beliefs across the continuum of psychosis: comparisons between patients w... 6523126 - Trace elements in brains of patients with alcohol abuse, endogeneous psychosis and schi... 3048186 - Rapid tissue expansion in the treatment of myelomeningocele. 16532146 - Inflammatory myopathies in childhood: correlation between nailfold capillaroscopy findi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-15 |
Journal Detail:
|
Title: Psychiatry research Volume: 162 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-02-04 Completed Date: 2008-05-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
|
Languages: eng Pagination: 101-11 Citation Subset: IM |
Affiliation:
|
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. tsutomu@med.u-toyama.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amygdala / abnormalities*, pathology Dominance, Cerebral / physiology Female Gyrus Cinguli / pathology Hippocampus / pathology Humans Image Processing, Computer-Assisted* Magnetic Resonance Imaging* Male Nervous System Malformations / pathology* Neural Pathways / pathology Neuroglia / pathology Parahippocampal Gyrus / pathology Prefrontal Cortex / pathology Schizophrenia / pathology* Temporal Lobe / pathology Thalamus / abnormalities*, pathology Third Ventricle / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuropsychological function-brain structure relationships and stage of illness: an investigation int...
Next Document: Photografting of 2-methacryloyloxyethyl phosphorylcholine from polydimethylsiloxane: tunable protein...