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Association between Vitamin C deficiency and dialysis modalities.
MedLine Citation:
PMID:  22404236     Owner:  NLM     Status:  Publisher    
SUMMARY AT A GLANCE: The authors designed a cross-sectional study to investigate plasma vitamin C level in patients with HD and PD (total 382 patients). The results showed that 35.9% patients had severe vitamin C deficiency (<2µg/ml). Vitamin C deficiency was associated with HD. Thus, they concluded that vitamin C deficiency was common in dialysis patients, especially in those treated with HD. ABSTRACT: Aims:  We design a cross-sectional study to investigate plasma vitamin C level in patients underwent maintenance hemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD), and to explore whether there is a difference in vitamin C deficiency between MHD patients and CAPD patients. Methods:  This investigation included 382 dialysis patients without vitamin C supplement before the study. Demographic characteristics, laboratory tests, ascorbic acid and total plasma vitamin C level were measured. A linear regression model was built to explore the association between vitamin C deficiency and dialysis modalities after adjusting age, dialysis vintage, gender, Charlson index, modality of dialysis and hsCRP. Results:  The range of plasma vitamin C level was from 0.48 µg/ml to 31.16 µg/ml. 35.9% (n = 137) patients had severe vitamin C deficiency (<2µg/ml). Plasma vitamin C level was inversely associated with age and dialysis vintage. After age and dialysis vintage were adjusted, vitamin C deficiency was associated with MHD. R square for model fitting was relatively low, which implied that there was other vitamin C influencing factor not included in the model. Conclusions:  Vitamin C deficiency is common in dialysis patients, especially in patients treated with MHD. © 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Kunying Zhang; Jie Dong; Xuyang Cheng; Wenying Bai; Weiya Guo; Leiyun Wu; Li Zuo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
. Renal Division, Department of Medicine, Peking University First Hospital, Peking, PR China . Peking University Institute of Nephrology, Peking, PR China .Key Laboratory of Renal Disease, Beijing, PR China . Beijing Daxing district People's Hospital, China . Guangwai Hospital, Beijing, China . Beijing No. 2 Hospital, China.
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