Document Detail

Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertension.
MedLine Citation:
PMID:  22711274     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A high-sodium diet has little short-term effect on blood pressure in nonhypertensive individuals but, for unclear reasons, is associated with hypertension if consumed long term. We hypothesized that a chronically high sodium intake would be associated with increases in biomarkers of endothelial dysfunction, specifically serum uric acid (SUA) and urine albumin excretion (UAE), and that high sodium intake would be associated with incident hypertension among those with higher SUA and UAE.
METHODS AND RESULTS: We prospectively analyzed the associations between sodium intake and the change in SUA (n=4062) and UAE (n=4146) among participants of the Prevention of Renal and Vascular End Stage Disease (PREVEND) study who were not taking antihypertensive medications. We also examined the association of sodium intake with the incidence of hypertension (n=5556) among nonhypertensive participants. After adjustment for confounders, each 1-g-higher sodium intake was associated with a 1.2-μmol/L increase in SUA (P=0.01) and a 4.6-mg/d increase in UAE (P<0.001). The relation between sodium intake and incident hypertension varied according to SUA and UAE. For each 1-g-higher sodium intake, the adjusted hazard ratio for developing hypertension was 0.98 (95% confidence interval, 0.89-1.08) among those in the lowest tertile of SUA and 1.09 (1.02-1.16) among those in the highest tertile. Corresponding hazard ratios were 0.99 (confidence interval, 0.93-1.06) among participants whose UAE was <10 mg/d and 1.18 (confidence interval, 1.07-1.29) among those whose UAE was >15 mg/d.
CONCLUSIONS: Over time, higher sodium intake is associated with increases in SUA and UAE. Among individuals with higher SUA and urine UAE, a higher sodium intake is an independent risk factor for developing hypertension.
John P Forman; Lieneke Scheven; Paul E de Jong; Stephan J L Bakker; Gary C Curhan; Ron T Gansevoort
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-18
Journal Detail:
Title:  Circulation     Volume:  125     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-26     Completed Date:  2012-09-06     Revised Date:  2014-10-19    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3108-16     Citation Subset:  AIM; IM    
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MeSH Terms
Albuminuria / blood*,  epidemiology,  urine*
Biological Markers / blood,  urine
Cohort Studies
Follow-Up Studies
Hypertension / blood*,  epidemiology,  urine*
Longitudinal Studies
Middle Aged
Prospective Studies
Risk Factors
Sodium, Dietary / adverse effects*
Uric Acid / urine*
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Sodium, Dietary; 268B43MJ25/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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