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Association between Sickle Cell Anemia and Pulp Necrosis.
MedLine Citation:
PMID:  23321227     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The purpose of this study was to evaluate the association between sickle cell anemia (SCA) and pulp necrosis (PN).
METHODS: One hundred thirteen individuals with SCA (ie, the exposed group) from the Supervision of Hematology and Hemotherapy of Maranhão (HEMOMAR), Maranhão, Brazil, and 226 individuals without SCA, the sickle cell trait, or other diseases (ie, the nonexposed group) were enrolled in this study. All participants were over 16 years old and had at least 1 clinically intact permanent tooth. Patients with SCA and a history of lower alveolar nerve paresthesia and those who had suffered from vasoocclusive crises within the previous 6 months were excluded. PN of clinically intact permanent teeth without a history of orofacial trauma was diagnosed using the cold thermal test (CTT) and pulse oximetry adapted for dentistry (POD). Poisson regression was used to estimate the associations (P < .05).
RESULTS: In an unadjusted analysis, the occurrence of PN in clinically intact permanent teeth was 8.33 times higher in the exposed group than in the nonexposed group (P < .001). This association remained significant after adjusting for a history of orofacial trauma and folic acid use for the CTT and POD evaluations.
CONCLUSIONS: In conclusion, SCA is a potential risk factor for PN in clinically intact permanent tooth.
Cyrene Piazera Silva Costa; Erika Bárbara Abreu Fonseca Thomaz; Soraia de Fátima Carvalho Souza
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Publication Detail:
Type:  Journal Article     Date:  2012-12-05
Journal Detail:
Title:  Journal of endodontics     Volume:  39     ISSN:  1878-3554     ISO Abbreviation:  J Endod     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  D    
Copyright Information:
Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Postgraduate Program in Dentistry, School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.
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