Document Detail


Association between serum levels of MASP-2 and neutropenic febrile attacks in children with leukemia.
MedLine Citation:
PMID:  23020538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Infectious complications are a major etiology of morbidity and mortality in febrile neutropenic patients. Low serum mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) concentration may represent a risk factor for infection in leukemia patients receiving chemotherapy. This study evaluates the relationship between serum levels of MASP-2 with neutropenic febrile attacks in children with leukemia.
METHOD: This prospective cohort study conducted between 2009-2010, we measured baseline serum MASP-2 levels by enzyme-linked immunosorbent assay (ELISA) prior to chemotherapy in leukemia patients less than 14 years of age. The relationship of febrile neutropenia (FN) episodes and duration of hospitalization with MASP-2 concentration was analyzed.
RESULTS: We evaluated 75 children [38 girls (51%), 37 boys (49%); mean age, 61.6 ± 43.7 months]. There were 8 (10.7%) children with MASP-2 deficiency (< 200 ng/mL). Mean MASP-2 was 673.2 ± 288.7 ng/mL (range: 116-1112). Eight patients had no FN episodes. Of the 129 FN episodes recorded, 19 (average 2.4 times) were from the MASP-2deficient group and 110 (average 1.6 times) were in the normal group. There was a significant difference between the mean MASP-2 concentration and FN episodes (P = 0.043). There was an inverse relationship between FN episodes (r = -0.332, P = 0.004) and the duration of hospitalization (r = -0.334, P = 0.005) with MASP-2 concentration. MASP-2 deficient patients were hospitalized longer than the normal group, which was strongly significant (P < 0.001).
CONCLUSION: Our study confirmed the results of several previous studies. MASP-2 deficiency in leukemic children treated with chemotherapy was associated with an increased risk of FN episodes, prolonged cumulative duration of hospitalization, and intravenous antimicrobial therapy.
Authors:
Shiva Nazari; Mohsen Ebrahimi; Fatemeh Abdollah Gorji; Alireza Abadi; Alireza Fahimzad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-04     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Affiliation:
Department of Pediatric Hematology Oncology, Pediatric Infectious Research Center (PIRC), Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. shnazari2000@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Fever / enzymology*,  etiology
Humans
Infant
Length of Stay / statistics & numerical data
Leukemia / complications*,  drug therapy*
Male
Mannose-Binding Protein-Associated Serine Proteases / analysis*
Neutropenia / enzymology*,  etiology
Predictive Value of Tests
Prospective Studies
Statistics, Nonparametric
Chemical
Reg. No./Substance:
EC 3.4.21.-/MASP2 protein, human; EC 3.4.21.-/Mannose-Binding Protein-Associated Serine Proteases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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