| Association between serum insulin-like growth factor (IGF) I and IGF binding protein-3 and lung function. | |
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MedLine Citation:
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PMID: 19401363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is strong evidence that IGF-I and IGF binding protein 3 (IGFBP-3), as central mediators of endocrine and finally metabolic or anabolic effects of GH, were associated with increased lung size in acromegaly or a decrease of respiratory muscle pressures in patients with GH deficiency. The aim of the present study was to further clarify the impact of IGF-I and IGFBP-3 levels on lung volumes and respiratory pressures in a general adult population. MATERIAL AND METHODS: From the Study of Health in Pomerania, 1326 subjects aged 25 to 85 yr participated in standardized pulmonary function testing. IGF-I and IGFBP-3 levels were measured with the Immulite 2500 system. Multivariable linear regression analyses adjusted for age, sex, body mass index, physical activity, and smoking were performed. RESULTS: In men, positive linear associations between IGF-I and IGF-I/IGFBP-3 ratio with forced expiratory volume in 1 sec (FEV1) as well as with forced vital capacity (FVC) were detected across all ages, whereas in women this positive association was only detectable above 50 yr. Furthermore, the analyses indicated positive linear relations of IGF-I/IGFBP-3 ratio with FEV1 and FVC, respectively. No significant relations between IGF-I or IGFBP-3 and maximal inspiratory pressure was detectable in both sexes. CONCLUSION: In conclusion, higher IGF-I levels were associated with higher lung volumes in men, whereas in women this association was only detectable in subjects older than 50 yr. Higher IGF-I values were not associated with increased respiratory muscle strength measured as maximal inspiratory pressure. |
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Authors:
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Sven Gläser; Nele Friedrich; Ralf Ewert; Christoph Schäper; Matthias Nauck; Marcus Dörr; Henry Völzke; Stephan B Felix; Alexander Krebs; Henri Wallaschofski; Beate Koch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-28 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 94 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-08 Completed Date: 2009-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2452-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine B, Pulmonary Medicine and Infectious Diseases, Ernst-Moritz-Arndt University Greifswald, D-17475 Greifswald, Germany. glaeser.sven@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Growth Disorders / blood, physiopathology Humans Insulin-Like Growth Factor Binding Protein 3 / analysis, blood* Insulin-Like Growth Factor I / analysis* Lung / physiology* Male Middle Aged Respiratory Function Tests Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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