Document Detail


Association between PPARγ2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China.
MedLine Citation:
PMID:  22653647     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Activation of the peroxisome proliferator-activated receptor g (PPARg) improves insulin sensitivity and inhibits atherosclerosis. Whether PPARg2 Pro12Ala polymorphism affects myocardial infarction is not clearly understood. We investigated a possible association of PPARg2 Pro12Ala polymorphism with obesity and myocardial infarction in Han Chinese in Hohhot, Inner Mongolia, China. We included 121 subjects with myocardial infarction and 137 healthy controls in our study. Triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured. The following information was recorded for each subject: age, gender, body height, body weight, systolic blood pressure, and diastolic blood pressure; the body mass index was calculated. PCR-RFLP was used to examine Pro12Ala polymorphism. There were significant differences in clinical characteristics between myocardial infarction patients and healthy controls, except for diastolic blood pressure and triglycerides. The PP, PA/AA genotype frequencies were 88.4 and 11.6% in myocardial infarction patients and 95.6 and 4.4% in controls, respectively (P = 0.031). Individuals with the A allele had a significantly higher risk of myocardial infarction. The A allele was not an independent risk factor for obesity. We conclude that PPARg2 Pro12Ala polymorphisms are associated with increased risk for myocardial infarction in Han Chinese in Hohhot.
Authors:
L P Wang; L R Zhao; H W Cui; M R Yan; L Yang; X L Su
Related Documents :
9799657 - Chronic k-supplementation decreases myocardial [na,k-atpase] and net k-uptake capacity ...
9731627 - Photothrombotic middle cerebral artery occlusion in spontaneously hypertensive rats: in...
11710787 - Effect of ace/nep inhibition on cardiac and vascular collagen in stroke-prone spontaneo...
16908757 - Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phas...
8237747 - Short- and long-term neurohormonal activation following acute myocardial infarction.
2933527 - Regional myocyte size in compensated right ventricular hypertrophy in the ferret.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  11     ISSN:  1676-5680     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology of Affiliated Hospital, Inner Mongolia Medical College, Hohhot, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-...
Next Document:  SCAR markers for discriminating species of two genera of medicinal plants, Liriope and Ophiopogon.