Document Detail

Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography.
MedLine Citation:
PMID:  24583418     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. How up-regulation of monocyte subsets leads to coronary plaque rupture followed by thrombus formation remains unclear. Recent studies have shown that P-selectin glycoprotein ligand-1 (PSGL-1) is involved in monocyte activation in patients with thrombus formation. We therefore investigated the relationship between the expression of PSGL-1 on monocyte subsets and thrombus formation using frequency-domain optical coherence tomography (FD-OCT) in patients with ACS.
METHODS: We enrolled a total of 100 individuals in this study: patients with acute myocardial infarction (AMI, n = 25), unstable angina pectoris (UAP, n = 20), or stable angina pectoris (n = 35) who underwent coronary angiography, and control subjects (n = 20). Three monocyte subsets (CD14(++)CD16(-), CD14(++)CD16(+), and CD14(+)CD16(+)) and the expression of PSGL-1 were measured by flow cytometry. In patients with AMI and UAP, FD-OCT was performed before percutaneous coronary intervention.
RESULTS: Circulating peripheral CD14(++)CD16(+) monocytes expressed PSGL-1 more frequently than CD14(++)CD16(-) and CD14(+)CD16(+) monocytes in patients with ACS. The expression of PSGL-1 on circulating peripheral CD14(++)CD16(+) monocytes was significantly elevated in patients with AMI compared with the other 3 groups. Moreover, the expression levels of PSGL-1 on CD14(++)CD16(+) monocytes were significantly higher in patients with plaque rupture or intracoronary thrombus assessed by FD-OCT.
CONCLUSION: Up-regulation of PSGL-1 on CD14(++)CD16(+) monocytes may be a crucial role in plaque rupture and thrombus formation.
Yuichi Ozaki; Toshio Imanishi; Ikuko Teraguchi; Tsuyoshi Nishiguchi; Makoto Orii; Yasutsugu Shiono; Kunihiro Shimamura; Kohei Ishibashi; Takashi Tanimoto; Takashi Yamano; Yasushi Ino; Tomoyuki Yamaguchi; Takashi Kubo; Takashi Akasaka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-28
Journal Detail:
Title:  Atherosclerosis     Volume:  233     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-3-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  697-703     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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