Document Detail


Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population.
MedLine Citation:
PMID:  22347434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.
METHODS: We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
RESULTS: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
CONCLUSIONS: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.
Authors:
Irene Marta Predazzi; Giuseppe Danilo Norata; Lucia Vecchione; Katia Garlaschelli; Francesca Amati; Liliana Grigore; Lucia Cutuli; Angela Pirillo; Simona Tramontana; Francesco Romeo; Giuseppe Novelli; Alberico Luigi Catapano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-09
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-07-31     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31086     Citation Subset:  IM    
Affiliation:
Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Rome, Italy. irene.m.predazzi@Vanderbilt.Edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Carotid Artery Diseases / epidemiology,  genetics*,  pathology*
Carotid Artery, Common / pathology*
Female
Genotype
Humans
Inflammation
Macrophages
Male
Polymorphism, Single Nucleotide*
Scavenger Receptors, Class E / genetics*
Sex Factors
Tunica Intima / pathology
Tunica Media / pathology
Grant Support
ID/Acronym/Agency:
2T32HL007751-16A2/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/OLR1 protein, human; 0/Scavenger Receptors, Class E
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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